| [Objective] Observation of the clinical efficacy of the treatment of metabolic syndrome by the wuling powder and to explore some of its mechanism of action.[Methods] The80patients corresponding with the diagnostic criteria were randomly divided into treating group of40patients and control group of40patients. The control group take a primary interventions of based on healthy lifestyle and regard controling blood sugar, blood pressure, blood fat as the secondary interventions. The treatment group added the wuling powder based on the interventions of the control group. The course of treatment was tweleve weeks. Compared with the Traditional Chinese Medicine syndrome, waist circumference, weight, body mass index, blood pressure, blood lipids, blood glucose, insulin function, serum inflammatory markers (high sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-a), adipocytokines (adiponectin, leptin), vascular endothelial function (nitric oxide, endothelin, brachial artery flow-mediated dilation diameter) and toxicity before and after treatment of all patients.[Results] The aspect of improving TCM syndromes, as for the treatment group,14cases were significantly effective,20cases were effectual and6cases were unfruitful with a total effective rate of85%. In40cases of control group,11cases were significantly effective,19cases were effectual, the total effective rate was75%, The rate of excellent and total effective were superior to the control group (P<0.05或P<0.01). The aspect of decreasing the waist circumference, weight, body mass index, the differences were statistically significant comparing with the two groups (P<0.01or P<0.05). As for the treatment group, the fall degree of waist circumference, weight, body mass index were (8.65±4.82) cm,(7.46±4.72) kg,(4.39±1.87). As for the control group, the fall degree were (7.93±0.81) cm,(6.29±2.88) kg,(3.19±2.48), the differences were all statistically significant(P<0.01). There was statistically significant difference before and after treatment of treatment group with respect to improving systolic pressure and diastolic pressure(P <0.01), but there was no statistically significant difference in the control group (P>0.05). The aspect of decreasing blood fat, the two groups could significant decrease the level of TC,LDL-C, they all have statistically significant difference(P<0.01);After treatment, the level of HDL-C significant increased in treatment group (P<0.01), there was no obvious change in control group(P=0.079), the treatment group were superior to the control group (P<0.01). After treatment, there was statistically significant difference of two group with respect to decreasing the level of FBG,PGO.5h, PGlh,PG2h,PG3h,HbAlc (P<0.01);Comparing with the control group, the treatment group were superior to the control group aspect to decreasing FBG and PGO.5h. After treatment, there was statistically significant difference in treatment group respect to decreasing the level of INS0.5h,INS2h, increasing the level of REISI, decreasing the level of FINS,INSlh,INS3h, HBCI,MBCI (P<0.05or P<0.01). There was statistically significant difference in control group respect to decreasing the level of INSO.5h,HBCI, increasing the level of△I30/△G30, decreasing the level of FINS,INSlh,INS3h,HBCI, MBCI (P<0.05or P<0.01). Comparing with the control group, the treatment group were superior to the control group aspect to decreasing FINS,MBCI(P <0.05), there was statistically significant difference aspect to increasing the level of REISI (P<0.01). After treatment, there were statistically significant difference in two groups respect to decreasing the level of IL-6, TNF-α and hs-CRP (P<0.05). Comparing with the control group, the treatment group were superior to the control group aspect to decreasing the level of IL-6,TNF-α and hs-CRP (P<0.05). After treatment, there were statistically significant difference in two groups respect to decreasing the level of LEP and increasing the level of APN (P<0.05or P<0.01). Comparing with the control group, the treatment group were superior to the control group aspect to decreasing the level of LEP and increasing the level of APN (P<0.01). Comparing with the control group, the treatment group were superior to the control group aspect to imoprving the NO,ET,NO/ET and increasing the level of FMD (P<0.05). The treatment group had less side effects, the safety was higher.[Conclusion]The wuling powder could not only improve clinical symptoms and signs, decreased waist circumference, weight and body mass index, blood pressure control, blood sugar, blood lipids but also had better intervation of the important laboratory index including the level of insulin secretion, serum inflammatory markers (IL-6, TNF-α and hs-CRP), adipocytokines (LEP, APN), vasoactive substances (ET, NO, NO/ET). Through improving insulin secretion and relieving insulin resistance, decreasing inflammation, correcting leptin resistance, increasing the low-fat adiponectin levels and regulating vasoactive substances, the wuling powder play the effect of its treatment of metabolic syndrome. The wuling powder is worthy of popularization and further research because of the better effects and less side effects. |
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