Study Of Kidney-qi Pill Comparation Between Prescription And Syndrome

Objective:to deepen the understanding of kidney-qi pill by reviewing ancient relevant literatures and sorting out modern clinical proved cases, so as to discover the impersonality and standard correspondences between prescription and syndromes.Method:The author reorganized the literatures of kidney-qi pill to deepen the understanding by reviewing the original record of kidney-qi pill written by Zhang Zhongjing and relevant data analyzed by the ancient and modern famous physicians. To do the statistic analysis of frequency for the symptoms and signs, frequency and amount of the herbs, modified herbs of kidney-qi pill, the author sorted the modern clinical proved cases into normal cases and sought the essential and major symptoms and pulse of the prescription by golden section method. Therefore, in order to find the correlation between the prescription and syndromes, the association rules was used to analyze the relationships among symptoms and pulse, herbs as well as symptoms and herbs. At last considering the dosage of the essential herbs in the prescription as the standardization, the author made a conclusion on the correspondences between syndromes and prescription by the method of clustering analysis to observe the different groups.Results:①It is commonly used in patients aged between 40 and 64, which conforms to the records of "At the age of forty, as Shenqi (Kidney-Qi) declines... At sixty-four he loses his teeth and his hair."in Treatise on the Natural Truth in Ancient Times.②The disease process:It lasts mainly more than 6 months, most of which are 1-3 years.③Disease in TCM:The most is syndrome patterns of kidney, followed by syndrome patterns of qi, blood and body fluid, ENT and the lung.④Common disease spectrum:The most is in the urinary system diseases, followed by circulatory diseases, respiratory diseases;⑤Symptoms and signs (≥38.2%):weak and sore loins and knees 62.00%, abnormal urination60.75%, aversion to cold 59.50%, lusterless complexion 44.25%, lassitude 37.50%, pale tongue 62.73%, white fur 59.06%, thin fur 40.16%, deep pulse68.89%, thread pulse60.41%.⑥Herbs usage (≥38.2%): Shudihuang(Radix Rehmanniae Preparata), Shanyao(Rhizoma Dioscoreae), Shanzhuyu(Fructus Corni), Fuling(Poriae), Zexie(Rhizoma Alismatis), Danpi(Cortex Moutan Radicis), Fuzi(Radix Aconiti Lateralis Preparata), Rougui(Cortex Cinnamomi), and the modified herbs mainly are strenthening qi and tonifying yang.⑦Cluster analysis:6 goups, in which the third group, low-dose group is the largest (202 cases), followed by the second group (116 cases) and the fifth group (69 cases), the high-dose of Dihuang(Radix Rehmanniae Preparata) group and the high-dose of Fuzi(Radix Aconiti Lateralis Preparata) group repectively.⑧Association rules analysis:the associations among herbs, symptoms and pulses as well as the herbs and symptoms and pulses, which indicate the high degree of correspondences between prescriptions and syndromes in kidnwy-qi pill.Conclusion:①Symptoms and pulse:The essential symptoms and pulse of kidney-qi pill are weak and sore loins and knees, pale tongue and deep pulse; the main symptoms and pulse of kidney-qi pill are abnormal urination, aversion to cold, lusterless complexion, lassitude, white thin coating, thready pulse, which reveal that the pathogenesis of the prescription is deficiciency of kidney-qi, and qi deficiency leading to yang deficiency.②The essential herbs:Shudihuang(Radix Rehmanniae Preparata), Shanyao(Rhizoma Dioscoreae), Shanzhuyu(Fructus Corni), Fuling(Poriae), Zexie(Rhizoma Alismatis), Danpi(Cortex Moutan Radicis), Fuzi(Radix Aconiti Lateralis Preparata), Rougui(Cortex Cinnamomi).③Cluster Analysis:The varieties of the herbs dose lead to the certain changes of the symptoms and pulse, which shows the correspondence of between prescriptions and syndromes; the differences of the three main groups are focus on Shudi, Fuzi and Shanyao.④Association rules analysis: Strong relevant relationships among herbs, symptoms and pulses as well as herbs and symptoms and pulses reveal the strong correlations between Shenqi pill and syndromes.Above all, through clustering and association rules analysis, the author found the pathogenesis of kidney-qi pill and its specific and standard relationship with syndromes, so that modified kidney-qi pill can be used properly in clinic.