Study On The Influence Factors Of Oriented Efficacy Exertion Of Huanglian (Rhizoma Coptidis) In Formula

Objective:To research the regulating factors that controlling the function of Huanglian(Rhizoma Coptidis) in formula.Methods 1070 formulas with huanglian were structured data bank in Micro-Excel, according to the classic format Formula Dictionary of Traditional Chinese Medicine. Statisticsing and analyzing the effectiveness influence factors of Huanglian including compatibility, dosage, processing, dosage form, usage and provenience place by statistic methods of classification.Results:The four kinds of concluded Huanglian's efficacy are clearing heat and dampness, clearing away heat purging fire, clearing away heat and toxic materials and invigorating the stomach with bitter and cold natured. Clearing heat and dampness, clearing away heat purging fire and clearing away heat and toxic materials are Direct effect. Invigorating the stomach with bitter and cold natured is Indirect effect. The regulating factors that controlling functional exertion of Huanglian in formula are the circumstances of compatibility, dosage, processing of Huanglian, preparation, usage and origins of Huanglian. The circumstances of compatibility is the most important regulating factors. When exerting function of removing fire from the heart, Huanglian is usually made up a prescription with Ejiao (Colla Corii Asini), Rougui(Cortex Cinnamomi), Gancao(Radix Glycyrrhizae). When exerting function of removing fire from the liver, Huanglian is usually made up a prescription with Longdancao(Radix Gentianae), Danggui(Radix Angelicae), Xiangfu (Rhizoma Cyperi). When exerting function of removing fire from the stomach, Huanglian is usually made up a prescription with Shengma(Rhizoma Cimicifugae), Suye (Folium Perillae), Banxia(Rhizoma Pinelliae), Dahuang(Radix et Rhizoma Rhei). When exerting function of clearing heat and dampness, Huanglian is usually made up a prescription with Muxiang (Radix Aucklandiae), Houpu(Cortex Magnoliae),Rougui (Cortex Cinnamomi).When exerting function of clearing away heat and toxic materials,Huanglian is usually made up a prescription with Huangqin (Radix Scutellariae), Huangbai(Cortex Phellodendri), Zhizi(Fructus Gardeniae).When exerting function of invigorating the stomach with bitter and cold natured, Huanglian is usually made up a prescription with Baizhu (Rhizoma Atractylodis Macrocephalae), Shenqu(Massa Fermentata Madicinalis). Fresh Huanglian is good to clear away heat and toxic materials. Huanglian processed with wine is good to clear fire from the upper-energizer. Huanglian processed with fresh ginger is good to clear fire from the middle-energizer. The small dosage of Huanglian is good to invigorate stomach. The middle dosage of Huanglian is good to clear away heat purging fire and toxic materials. The big dosage of Huanglian is good to clear heat and dampness. Decoction apply to clear heat and dampness, clear away heat purging fire, clear away heat and toxic materials. Pill is often used to invigorate the stomach.Conclusion:The compatibility is the key point of all factors influencing the efficacy of Huanglian. What is more, other factor including dosage, processing, dosage form, usage and provenience place are also influential. Therefore, the efficacy exertion of Huanglian in compound formus is influenced by all the factors were mentioned above.