| Today, isolated systolic hypertension has become one of the main diseases of threaten the human health. Along with our country old population quantity's increase, the ISH disease incidence rate also assumes gradually the trend of escalation in our country. Now some researchs had confirm that ISH is the most common hypertension hypotype in the old age crowd, occupies old age hypertension crowd more than half. Simultaneously ISH is one of senior citizen's important cardiovascular hazard factors, its and cardiovascular disease's formation rate and the case fatality rate present are related, his/her the cardiovascular complication's disease incidence rate and the case fatality rate are blood pressure normal person's 3 times, and the early kidney function harm relations are close. Although the humanity has spent the massive manpower, the financial resource research to treat ISH the effective medicine, but so far it has the inevitable side effect. Therefore began from the Chinese medicine aspect, to seek treats ISH the effective medicine already to become hypertension to prevent and control the domain an important domain. At present up to, although there already had many reports to traditional Chinese medicine preparation applied to reat ISH,but related treats ISH the compound prescription prepared medicine and closes with these traditional Chinese medicine preparation treats ISH the mechanism research not to see the report, this topic is the plan makes a beneficial exploration in this domain.This research institute uses the preparation Compound Qima Capsules(CQC)is Invented by Professor Wang Qinghai,who based on the Chinese medicine basic theory, summarizes the Chinese medicine dialectical minute which earnestly modern hypertension gets sick, unifies oneself dozens of years to practice medicine the experience to develop after the proven prescription. Many years'clinical practice has confirm that Compound Qima Capsules can descense hypertension Effectively, especially has the accurate curative effect to old ages who with isolated systolic hypertension. But until present there is not any research about the mechanism of Compound Qima Capsules treating isolated systolic hypertension. this study was a beneficial evaluation in this field. Experiment StudyOBJECTIVE:To observe the effect of Compound Qima Capsules(CQC)for the level of Hcy,TC,TG,LDL-C,LP(a) of rice with isolated systolic hypertension(ISH), to evaluate the mechanism of Compound Qima Capsules(CQC) to treatment of ISH by using the experimental model of rats.METHODS:SD rats were randomized into six group:healthy group, blank group, control group, high dose,moderate and low dose group. To establish rats model with the model of WVK, with the medols such as the electron microscopic cytochemistry of enzyme, molecular biologic technique and immunohistochemical technique, to evaluate the mechanism of Compound Qima Capsules (CQC) to treatment of ISH. This study includes 3 parts. Part 1:To observe the effect of Compound Qima Capsules (CQC) for the level Hcy to evaluate the he mechanism of Compound Qima Capsules(CQC) to treatment of ISH. Part 2:observation on the effect of Compound Qima Capsules(CQC) on the blood pressure and blood fats, to evaluate the mechanism of decending blood pressure and improves the degre of arteriosclerosis. Part3:by pothology to observe the effect of Compound Qima Capsules(CQC) modifies the degree of arteriosclerosis of mouse, To offer experimental evidence about CQC treat ISH.RESULTS:(1) Comparion about the blood between pre-model and post-model model: compare to the healthy group, the systolic blood pressure level of model groups were markedly increased from the third week, there were significant differences between the two groups(P<0.05); while there was no significant differences between the diastolic pressure. A design of oneself comparion according to pre-model and post-model was performed in different dose groups. There was significant difference in systolic pressure in model group(P<0.05), while there was no significant difference in diastolic pressure. That means it is successful in copy model.(2) Comparion between model group and healthy group:the blood Hey level of model group was markedly increased, there were significant difference s between the two groups(P<0.05), that means The blood Hey level and the ISH occurrence has the close relation.(3) Comparison of the effect of decending blood Hey:the blood level of Hey reduce markedly in the low dose, moderate and high dose group. that means Compound Qima Capsules(CQC) can effectively reduce the level of blood Hey of rats with isolated systolic hypertension(4) Compare to blank group, there was some reduce in the level of blood Hey after post-treatment, especially in high dose group, There were significant differences (P<0.01). that means Compound Qima Capsules (CQC) can reducing the level of blood Hey of ISH rats, while the effect is related to dose.(5)Comparion of systolic pressure pre-treatment and post-treatment: compare to blank group, the systolic pressure of Nifedipine group reduced obviously in the first week, There were significant differences (P<0.01). While the the systolic pressure of CQC groups reduced markedly from the third week,there were significant differences only in model and high dose groups. After treating four weeks, there were no differences in systolic pressure between CQC high dose group and Nifedipine group, that means high dose of CQC has the same efficacy as Nifedipine Tablets in decreasing systolic pressure.Compare to blank group in the same time and pre-treat, systolic pressure has markedly reduced in different dose group, there were significant differences(P<0.05), while reduced most in high dose group (P<0.01). That means the effecy of CQC on decending systolic pressure is related to dose.(6)Comparion of diatolic pressure between blank group and pre-treatment:Compare to blank group in the same time and pre-treatment, diatolic pressure of Nifedipine group reduced markedly, there were significant differences (P<0.05). While there were no significant differences in CQC groups after treatment, compare to blank group in the same time and pre-treatment (P>0.05). That means CQC has little effect on diatlic pressure.(7) Comparion of blood fats pre-treatment and post-treatment:the level of TC,TG,LDL-C,LP(a) increases markedly of the control groups compares to the blank groups, that means existent fat metabolic disorder in rats with isolated systolic hypertension. Compare to blank group, the level of blood TG,TC,LDL,LP(a) reduce obviously, there were significant differences, that means CQC can effectively interven level of blood fats of ISH rats. But it reduced most in the high dose group, comparion among different dose groups, there were significant differences, that means the effecy of CQC on decending blood fats level is related to dose.(8) The pathology test result of rats'abdomen aorta:Compares with the healthy group:the blank group aorta tunica media vasorum structure, the shape see obvious change, the accumulation are obvious, showed that the ISH animal model duplicates successfully. Compares to the Nifedipine group, the medium and high dose group has not seen the obvious change, the tunica media vasorum accumulation are not obvious; The low dose group aorta tunica media vasorum structure, the shape see the obvious change, explained that the compound prescription qi hemp capsule improvement arteriosclerosis the degree and the dosage have the close relation.CONCLUSION:(1) The Compound Qima Capsules can reduce the level of blood Hey of rats with isolated systolic hypertension, and its effect is related to the quantity.(2) The compound Qima Capsules can decend the systolic pressure obviously of rats with ISH, and has little influence on dialotid pressure, but the effect in reducing blood pressure has the effect quantity relations.(3) The Compound Qima Capsules can reduce the level of blood fats of rats with isolated systolic hypertension, and the effect is related to the dose.(4) CQC can effectively reduce the sclerosis degree of aortaventralis with ISH, and the effect is related to dose. Clinical StudyOBJECTIVE:To observe the clinic effect of Compound Qima Capsules (CQC) for the treatment of isolated systolic hypertension (ISH) with Qi deficiency and phlegm turbidity.METHODS:A prospective study was done of Qi deficiency and phlegm turbidity in 60 patients with ISH under the randomized, controlled and single-blind rules. These patients were randomized into control and experimental groups in 1:1 proportion. These patients in experimental group received CQC; while the patients in control group received extended-release Nifedipine Tablets.To compare the clinic efficiency to the patients in control and experimental groups by observing the change of hypertension and the change of traditional Chinese medicine syndrome and symptom before and after treatment.RESULTS:(1) Comparion of the efficacy to blood pressure after treatment:the results of therapy were assessed as follows:the general effective rate being 86.7% in treatmental group, while 93.3% in control group, there was not significant differences between the two groups (P>0.05). It means that the two groups has same effect.(2) Compare of the results of 24h ambulatory blood pressure:A design of oneself comparison according to pre-treatment and post-treatment was performed in both groups. There was significant differences in each group(P<0.05). The comparisons of 24h ambulatory blood pressure between two groups after treatment:there was not significant differences between the two groups(P>0.05). It illustrates that the two groups has same effect. The compariison in smoothness index between two groups after treatment:there was significant differences between two groups,that means the effect of CQC is moderater than Nifedipine Tablets.(3) Compare of the efficacy to traditional Chinese medicine syndrome between control and experimental group:the general effective rate being 93.3% in treatmental group; the general effective rate being 73.3% in control group, there were significant differences between the two groups(P<0.05).(4) Compare of the scores of traditional Chinese clinical symptoms between control and experimental group:A design of oneself comparison according to pre-treatment and post-treatment was performed in both groups. There were significant differences between pre-treatment and post-treatment in each group (P<0.05). The value between pre-treatment and post-treatment in experimental group had significant difference to that in control group(P<0.05).(5) Compare of the traditional Chinese medicine symptom between control and experimental group:the general effective rate to god tired strength being 89.7% in experimental group, while 60.0% in control group. there were significant differences between the two groups (P<0,05). The general effective rate to head heaviness being 80.8% in experimental group, while 47.8% in control group. there were significant differences between the two groups(P<0,05). the genenral effective rate to dizziness being 83.3% in experimental group, while 50% in control group. there were significant differences between the two groups(P<0,05).There were no significant differences of other symptom between the two groups(P>0.05).CONCLUSION:Through the observation of treatment of Compound Qima Capsules for for the treatment of 1.2 leve isolated systolic hypetension(ISH)with Qi deficiency and phlegm turbidity, we found that CQC has the same efficacy as Nifedipine Tablets in decreasing blood pressure,and has litter influence in dialotic pressure. But the improvement of traditional Chinese medicine syndrome and symptom, specially god tired strength,head heaviness and dizziness, is significantly increased in experimental group tha in control group. we also found that Compound Qima Capsule has lower side effect, so as to has a good prospect of application and extension.CONCLUDING:(1) The Compound Qima Capsules can reduce the level of blood Hcy of rats with isolated systolic hypertension, and its effect is related to the quantity.(2) The compound Qima Capsules can decend the systolic pressure obviously of rats with ISH, and has little influence on dialotid pressure,but the effect in reducing blood pressure has the effect quantity relations.(3) The Compound Qima Capsules can reduce the level of blood fats of rats with isolated systolic hypertension, and the effect is related to the dose.(4) CQC can effectively reduce the sclerosis degree of aortaventralis with ISH, and the effect is related to dose.(5) Through the observation of treatment of Compound Qima Capsules for for the treatment of 1.2 leve isolated systolic hypetension(ISH)with Qi deficiency and phlegm turbidity, we found that CQC has the same efficacy as Nifedipine Tablets in decreasing blood pressure, and has litter influence in dialotic pressure. But the improvement of traditional Chinese medicine syndrome and symptom, specially god tired strength,head heaviness and dizziness, is significantly increased in experimental group tha in control group. we also found that Compound Qima Capsule has lower side effect, so as to has a good prospect of application and extension. |
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