Smoking/Drinking And Psoriasis: Meta-analysis Of Case-control Studies

PART I: Smoking and Psoriasis: a meta-analysis of case-control studiesBackground: Psoriasis is one of the most common dermatological disorders. The association between smoking and psoriasis has been inconsistent among studies.Objectives: To examine the magnitude of the risk of developing psoriasis for smoking populations compared to those with nonsmoking, and to determine causes of the variation in OR between various case-control studies, we performed a comprehensive literature search and a meta-analysis of case-control studies considering prevalence.Methods: We did electronic searches on Medline, and searched reports to identify case-control studies of prevalent of psoriasis. We did meta-analyses of study-specific incremental estimates to determine the risk of psoriasis associated with smoking.Results: The magnitude of the OR was analyzed by combining 19 case-control studies that matched defined criteria. The variance in OR between studies was explored. The overall OR of psoriasis for smoking persons compared to those with nonsmoking was 2.005 (95% CI: 1.763-2.280) and for Current-Never and Formerly-Never comparisons was 1.881(95% CI: 1.303-2.714) and 1.797(95% CI: 1.329-2.430) respectively. The variation in OR among studies was explored and it was found that the effect of heterogeneity was highly related with ethnicity, but not for gender.Conclusions: Smoking is associated with increased risk of psoriasis. These epidemiological observations should inform the exploration of biological mechanisms that link smoking with psoriasis. PARTâ…¡:Drinking and Psoriasis: a meta-analysis of case-control studiesBackground: Psoriasis is one of the most common dermatological disorders. The association between drinking and psoriasis has been inconsistent among studies.Objectives: To examine the magnitude of the risk of developing psoriasis for drinking populations compared to those with nondrinking, and to determine causes of the variation in OR between various case-control studies, we performed a comprehensive literature search and a meta-analysis of case-control studies considering prevalence.Methods: We did electronic searches on Medline, and searched reports to identify case-control studies of prevalent of psoriasis. We did meta-analyses of study-specific incremental estimates to determine the risk of psoriasis associated with drinking.Results: The magnitude of the OR was analyzed by combining 14 case-control studies that matched defined criteria. The variance in OR between studies was explored. The overall OR of psoriasis for drinking persons compared to those with nondrinking was 1.594(1.153-2.202) and for Asian and European was 1.938(0.756-4.971) and 1.797(95% CI: 1.329-2.430) respectively.Conclusions: Drinking is associated with increased risk of psoriasis. These epidemiological observations should inform the exploration of biological mechanisms that link drinking with psoriasis.