Research On The Rules Of Syndrome Differentiation Based On Parkinson Disease's Combination Of The Disease And The Syndrome

Objective:To extract the pivotal syndrome factors of Parkinson disease(PD) and tremor while telling the difference between them; to standardize the syndrome differentiation of PD and explore the rules of syndrome differentiation; to deepen the pathogenesis of PD by exploring the developing rules of it's syndromes.Method:The basic theory was studied by arranging the related ancient literatures systematically. After collecting modern clinical documents, the pivotal syndrome factors were extracted and the diagnostic criteria for PD were established using data mining. Referring to the research conclusion of tremor and integrating the modern pathology, the pathogenesis of PD was explored following the principle of discussing the syndrome according to the disease and combining the syndrome and the disease.Result:The pivotal syndrome factors of tremor were qi deficiency, yin deficiency, internal heat and blood deficiency and the mainly involved organs were liver and spleen. The pivotal syndrome factors of PD were yin deficiency,internal wind, blood stasis, qi deficiency, phlegm and blood deficiency and the mainly involved organs were liver and kidney. They shared the common factors of qi deficiency, blood deficiency and yin deficiency. They were both characterized by deficiency of root aspect and related to liver. The difference was that tremor was deficiency of liver-yin and liver-blood as the basic pathogenesis, deficiency of splenic-qi as the common pathogenesis; PD was deficiency of kidney essence and disturbance of liver-wind. The six pivotal syndrome factors extracted from PD had obtained 34 types of combination and the diagnostic criteria of the syndromes composed of the combinations were the diagnostic criteria of PD. The pathogenesis of PD is characterized by kidney deficiency as the root aspect and liver wind as the branch aspect and blood stasis due to deficiency. To put forward a new the pathogenesis hypothesis of PD-the axle's function of Liver-Kidney-Brain is losing balance,which center is kidney and which pivot is the du meridian.Conclusion:PD and tremor shared the similar sympotoms but differed in basic syndromes, pivotal syndrome factors and location. The method of combining the syndrome and the disease could be applied to the research of the syndrome differentiation rules of PD in order to standardize the syndrome differentiation system as well as enhance the uniformity of syndrome diagnosis.Referred to tremor and proved by western pathology, kidney deficiency was confirmed to be the basic pathogenesis of PD.