Research On The Pathogenesis And New Approaching On The Quantitative Diagnosis Of The Common TCM Syndromes Of Psychological Stress Public

1. AimsThe aim of the research is trying to combine the two theories of psychological stress and seven modes of emotions to develop and bring new ideas. The study takes the social crowd as the researching objects, which picks out the crowd of psychological stress from a big sample with the methods of epidemiology on the foundation of some psychological forms in order to find the mechanism and correlation factors of diseases resulted from the psychological stress and emotions and to make new approach of quantization the diagnosis of syndromes further, all of which are benefit for providing new base to the research of diseases resulted from the psychological stress and emotions.2. MethodsWe make further study of the original database basing on the research of the early topical team and senior fellow apprentices. First, we pick out index which emerging with higher pykno to establish new discriminate function and regression formula to make the quantization diagnosis of syndrome more reasonable on base of the original quantization research of four pure syndromes, second, we probe the pathogenesis of the four syndromes with statistical methods from the angle of relations: analyzing the important indexes of the impacts on pathogenesis basing on its sort, finding out the relations between the indexes and making theoretical discussion with correlation analysis and exploring factor analysis.3. Results and conclusions3.1 New approaching of quantitative diagnosisIn the original research, we use some kinds of methods to study the stagnation of liver-Qi syndrome, liver-Qi attacking spleen syndrome, hyperactive liver-QI attacking the stomach syndrome and deficiency of gut-QI syndrome, all of which are over fifty cases in number on the base of researching on the distributional rule of syndromes in crowd of psychological stress. This research picks out the indexes which emerged over 4 times with the formal methods and establish new diagnostic mode and get related results. The selecting of the indexes have more representative meaning and make more reasonable for the quantitative diagnosis which were never used before, so we call it new approaching.3. 1. 1 Stagnation of liver-Qi syndromeThe selected indexes: deprementia, sigh, string-pulse, distention and pain of lower abdomen, food-taking little, tantrum, spargosis, carmoisine of the body of the tongue and hypochondrium distending pain, in low spirits, vomiting, sentimental.We establish discriminative modes with the Bayes stepwise discrimminant and find the coincidence is above 92.2 percent, the sensitivity is above 89.8 percent, the specificity is above 94.6 percent.We establish regression model with Logistic regression and find the coincidence is above 93.4 percent, the sensitivity is above 92.7 percent, the specificity is above 94.1 percent.3. 1. 2 Hepatic qi attacking spleenThe selected indexes: deprementia, spargosis, hypochondrium distending pain, sorrowfulness and longing for crying, anorexia, string-pulse, decanta immediately after the abdominal pain and the pain relieved following, in low spirits, tantrum and sigh.We establish discriminative modes with the Bayes stepwise discrimminant and find the coincidence is above 95.9 percent, the sensitivity is above 95.9 percent, the specificity is above 95.9 percent. The result is close to the information of in the group with the knife-cutting method.We establish regression model with Logistic regression and find the coincidence is above 99.3 percent, the sensitivity is above 100 percent, the specificity is above 98.6 percent.3. 1. 3 Hyperactive liver-QI attacking the stomachThe selected indexes: carmoisine of the body of the tongue, deprementia, belching, hiccough, distending pain of middle region of the upper abdomen, distending pain of lower abdomen, swallow acerbity, abdominal distention and pain, sorrowfulness and longing for crying, string-pulse, non-straightforward of stool.We establish discriminative modes with the Bayes stepwise discrimminant and find the coincidence is above 92.7 percent, the sensitivity is above 96.4 percent, the specificity is above 89.1 percent. The result is close to the information of in the group with the knife-cutting method.We establish regression model with Logistic regression and find the coincidence is above 94.2 percent, the sensitivity is above 98.5 percent, the specificity is above 90.9 percent.3. 1. 4 Syndrome of deficiency of QIThe selected indexes: inability to stay alone for fear, awaken with a startle, tired and debility, afraid, hyperarousal and insomnia.We establish discriminative modes with the Bayes stepwise discrimminant and find the coincidence is above 92.3 percent, the sensitivity is above 86.5 percent, the specificity is above 98.1 percent. The result is close to the information of in the group with the knife-cutting method.We establish regression model with Logistic regression and find the coincidence is above 95.2 percent, the sensitivity is above 98.1 percent, the specificity is above 92.3 percent.Presentation of results: the diagnostic or discriminative modes erected by different methods that mentioned above have favorable diagnostic and discriminative effect. Bays stepwise discriminant has better application meanings.When the numerical data are consistent with the Gaussian distribution, we can use the Bayes stepwise discrimination. This method can judge the functions of each index by the standard discriminated function coefficient in discriminated and the knife-cutting method can judge the application of discriminant. Logistic regression has no strict requirement to the distribution of data, so it is more convenient whatever the data have or not normal distribution.3. 2 Pathogenesis researchSymptoms are the basic essence among the disease, syndromes and symptoms. Basing on the theoretical analysis, the main indexes selected in the diagnostic mode and the indexes which emerged in higher rate and discriminated function coefficient in discriminatory analysis, the research try to study the location of significance of every symptoms, the relationship among symptoms with correlation analysis, find out the latent variance with exploring factor analysis and new road of the pathogenesis research from the relation angle in order to rich and consummate the pathogenesis research in methods.3. 2. 1 Theoretical study: Study the relations between psychological stress and stagnation of liver-QI, liver-qi attacking spleen, liver-qi attacking stomach and Deficiency of gut-QI syndromes and the respective pathogenesis of which.3. 2. 2 Study of rank of the significance of symptoms: Analyzing the pathogenesis meanings of the above 4 syndromes by the emergent rate and the discriminated function coefficient.3. 2. 2. 1 Stagnation of liver-QI syndrome: indexes which emerged 7 times in the 7 kinds of screening methods: deprementia, sigh, tantrum, spargosis, hypochondrium distending pain, carmoisine of the body of the tongue, string-pulse, food-taking little. There have no indexes which emerged 6 times. Indexes emerged for 5 times are in low spirits and sentimental. Indexes emerged for 4 times are vomiting.The rank from big to small of the symptoms basing on the number of the standard discriminated function coefficient are: deprementia, sigh, string-pulse, tantrum, spargosis, hypochondrium distending pain, in low spirits, distention and pain of lower abdomen, carmoisine of the body of the tongue, sentimental, vomiting and food-taking little.3. 2. 2. 2 Liver-qi attacking spleen syndrome: indexes which emerged 7 times in the 7 kinds of screening methods: deprementia, spargosis, hypochondrium distending pain. Indexes emerged for 6 times are sorrowfulness and longing for crying. Indexes emerged for 5 times are anorexy and string-pulse. Indexes emerged for 4 times are decanta immediately after the abdominal pain and the pain relieved following, in low spirits, tantrum and sigh.The rank from big to small of the symptoms basing on the number of the standard discriminated function coefficient are: spargosis, hypochondrium disteading pain, in low spirits, sigh, deprementia, decanta immediately after the abdominal pain and the pain relieved following, sorrowfulness and longing for crying, anorexy, tantrum and string-pulse.3. 2. 2. 3 Liver-qi attacking stomach syndrome: indexes which emerged 7 times in the 7 kinds of screening methods: indexes which emerged 7 times in the 7 kinds of screening methods: and non-straightforward of stools. carmoisine of the body of the tongue. Indexes emerged for 6 times are deprementia and belching. Indexes emerged for 5 times are hiccough. Indexes emerged for 4 times are distending pain of middle region of the upper abdomen, distention and pain of lower abdomen, swallow acerbity, abdominal distention and pain, sorrowfulness and longing for crying, string-pulse, non-straightforward of stool.The rank from big to small of the symptomes basing on the number of the standard discriminant function coefficient are: string-pulse, hiccough, deprementia, carmoisine of the body of the tongue, swallow acerbity, non-straightforward of stool, distending pain of middle region of the upper abdomen, hiccough, distention and pain of lower abdomen, sorrowfulness and longing for crying and abdominal distention and pain.3. 2. 2. 4 Deficiency of gut-QI syndrome: indexes which emerged 7 times in the 7 kinds of screening methods: inability to stay alone for fear, awaken with a startle, tired and debility. There have no indexes which emerged for 6 and 5 times. Indexes emerged for 4 times are insomnia and hyperarousal.The rank of the symptoms have no more the diagnostic meanings than can know the effects of the symptoms to syndromes in pathegenisis analysation.3. 2. 3 Study of the relations of syndromes3. 2. 3. 1 stagnation of liver-QI syndromes: we make relating analysis of the 12 symptoms selected from stagnation of liver-QI syndromes and find that there have direct correlations between deprementia and in low spirits, string-pulse, carmoisine of the body of the tongue, sigh and sentimental, and the difference have statistical significance, P＜0.05.We make principal component analysis of the 12 symptoms and find that there have 5 factors whose characteristic root are exceed 1. The 3 indexes dominated by Factorξ₁ represent negative emotional factors. The 3 indexes dominated by Factorξ₂ represent relating factors of qorry-tongue-pulse. The index dominated by Factorξ₃ represent sigh. The 3 indexes dominated by Factorξ₄ represent raged impairment-stagnant-reverse of stomach factors. The indexes dominated by Factorξ₅ represent stagnant and food-taking little factors.3. 2. 3. 2 Liver-QI attacking spleen syndromes: we make relating analysis of the 10 symptoms selected from liver-QI attacking spleen syndromes and find that there have direct correlations between deprementia and in low spirits and the difference have statistical significance, P＜0.05.We make principal component analysis of the 10 symptoms and find that there have 4 factors whose characteristic root are exceed 1. The 2 indexes dominated by Factorξ₁ represent morose factors. The 2 indexes dominated by Factorξ₂ represent sorrow factors. The 3 indexes dominated by Factorξ₃ represent pulse-syndrome relation factor. The index dominated by Factorξ₄ represent pulse factors.3. 2. 3. 3 Liver-QI attacking stomach syndromes: we make relating analysis of the 11 symptoms selected from liver-QI attacking stomach syndromes and find that there have no differences.We make principal component analysis of the 11 symptoms and find that there have 5 factors whose characteristic root are exceed 1. The 4 indexes dominated by Factorξ₁ represent stagnant of stomach-tough and pulse factors. The 2 indexes dominated by Factorξ₂ represent sorrow-pulse factors. The index dominated by Factorξ₃ represent depression of liver-QI factor. The index dominated by Factorξ₄ represent stagnant of stomach-qi factors. The index dominated by Factorξ₅ represent adverse rising of gastric qi factors.3. 2. 3. 4 Deficiency of gut-QI syndrome:: we make relating analysis of the 5 symptoms selected from deficiency of gut-QI syndromes and find that there have direct correlations between awaken with a startle and afraid and the difference have statistical significance, P＜0.05.We make principal component analysis of the 5 symptoms and find that there have 2 factors whose characteristic root are exceed 1. The 3 indexes dominated by Factorξ₁ represent deficiency of Qi-afraid relation factors. The 2 indexes dominated by Factorξ₂ represent heart-spirit scare factors.In stead of studying on technology, the research of pathogenesis mostly were limited to the rationalism of certain diseases or syndrome. In the approaching of the common syndromes and pathogenesis of psychological stress public, the research focused on the dependability of every two indexes for there always exist complicated relationships among indexes (symptoms) and the exploratory factor analysis can effetely find out the latent variance of the data, which mean the dependability is higher in one group and lower in different groups. Finding out some synthesis indexes of definite meanings and taking them as framework to decompose theoriginal variance into commonness and individual character, the aim of which is to perspective the relationship and difference between the original variances. This can simplify questions and promote the pathogenesis research in the point of view of relationship and mathematical statistics, explore new road and rich and consummate for the pathogenesis research in technology. It is an beneficial attempt although it still isn't mature and flawless.