| The main pathological mechanism of type 2 diabetes(T2DM) are insulin resistance(IR)and impairedβ-cell function, and now we think only if IR can't cause diabetes, it musthas impairedβ-cell function simultaneously, IR is the starting factor and impaired ofβ-cellfunction is decision factor. The impairedβ-cell function is always exist, not only in DMperiod, but also in prediabetic period and the group of non-diabetic fist relatives of patientswith T2DM.The cause of impairedβ-cell function is very complex, the main cause areglucotoxicity, lipotoxicity and inherit factor etc. They can increase theβ-cell burden, or/anddecreaseβ-cell number, change the quality, quantity and phase ofβ-cell, and then can'tmaintain the blood sugar level. PDX-1 is one of the hot point of research of DM in recentyears, it can regulate blood sugar by complex mechanism, including insulin and glucagonsecretion, increase the quantity ofβ-cell and inhibit it's apoptosis, and the improveβ-cellfunction and IR.The traditional Chinese medicine is consistent with guidance principle of therapy, whichimproveβ-cell function by the compound factors of decreasing bloody sugar, bloodcholesterol and remedy metabolic disorder. In the light of present therapeutic situation, theChinese medicine have a certain advantage in improvingβ-cell function. So our researchobserves the Kusuanzhitian, methods' effect on improvingβ-cell function and explains itsmechanism initially by clinical research and experiment research.In the part of theoretical study, the pathogenesis ofβ-cell function of T2DM, the studymethods, the present therapeutic study of Chinese and western medicine were summed up. Itargued the train of thought and methods which prevent and cure impairedβ-cell function oftype 2 diabetes, explaining the effect mechanism and the rule of Chinese medical principleand cure from the Kusuanzhitian, methods through the modern and archaic documentaryrecord examined from each Chinese department and school, which is reviewed andsummarized..Experimental part selected the experiment DM rats by 8 weeks high fat feeding andinjecting small dose STZ. We observe the expression of insulin, glucagons in pancreatic isletand GLUT-2 based on observing effect. Then we discuss the relationship of insulin, glucagonsand GLUT-2 to discover the micro-mechanism of Kusuanzhitian method improvingβ-cellfunction of T2DM.We can draw the conclusions from the clinical and experimental results thatKusuanzhitian method can produce a good curative effect on impairedβ-cell function inT2DM. Its mechanism has a lots of targets and links. From the results of clinics andexperiments, we can conclude the flowing:Kusuanzhitian treating method has a good effect on decreasing experiment DM rats'sblood sugar, improving the disorder of fat metabolism, and then can lighten the damage ofglucotoxicity and lipotoxicity toβ-cell function; increasing insulin secretion, area, index;improving the insulin secretion and insulin secretion index curve and protectingβ-cellfunction; increasing the expression of insulin in pancreatic islet and GLUT-2,PDX-1. Thenaddβ-cell' sensitivity to glucose inciting and outer side tissue insulin sensitivity, protectβ-cellfunction of pancreatic islet.In this research, we inquiry of therapeutic effect and its mechanism how Kusuanzhitiantreating method treat impairedβ-cell function of T2DM from different angel and level, developing the extension of clinical range after the modification of Kusuanzhitianfang. It willbe a new train of thought for the research of impairedβ-cell function of T2DM by Chinesemedicine. At the same time, it also establishes a firm foundation for the new Chinesemedicine explore of improvingβ-cell function. |
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