Study On The Effect And Antibiotics Resistance Mechanism Of Mycoplasma In Sexually Transmited Infections

Research Background and Objectives:Mycoplasma, the smallest self-replicating protest categorized between bacteria and viruses by size, can cause diseases in animals, plants and humans, especially in the respiratory and urogenital tracts. There are seven mycoplasma species with confirmed pathogenicity - Mycoplasma pneumonia(Mp), Ureaplasma urealyticum(Uu), Mycoplasma hominis(Mh), Mycoplasma genitalium(Mg), Mycoplasma fermentans(Mf), Mycoplasma penatrans(Mpe) and Mycoplasma pirum(Mpi). Expect for Mp,the other six species cause STD in humans. The last three are termed AIDS-related Mycoplasmas because of their relationship with the development of AIDS and outcomes. With the development of means of research and detection, more and more normal carriers of Uu and Mh are observed. Recently, some doubts have been raised to the pathogenicity of two Mycoplasmas and dealing with them differently in Clinic. Meanwhile, during essential treatment to Mycoplasma infection, people concerns its constant variations in virulence and changes in drug resistance. Besides, there are little studies to AIDS-related Mycoplasma in our country. In relation with this situation, funded by Natural Science Fund Committee (NSFC) and Jiangsu Preventive Medicine Fund, a series of research are conducted. The objectives are: 1. to fully understand the prevalence characteristics of Uu, Mh, Mg, Mf, Mpe and Mpi in HIV positives and AIDS patients, other STDs, high risk populations, female gential tract inflammation patients, healthy women and men; 2. to further discuss the pathogenicity among the female population; 3. to study the antibiotic resistance of Uu and Mh in order to suggest reasonable treatment regimens; 4. to probe into Uu's resistance mechanism against tetracyclines, fluoroquinolones (FQNS) and macrolides; 5. to study concurrent infection of Mycoplasmas and N. gonorrhoeae and the drug resistant mechanisms of the latter.