Experimental Research For Damage Of Seminiferous Function In Young Rats And It's Mechanism By Cytoxan

Antineoplastic drugs couldn't be substituted during synthetical cures for malignant tumors, preventing transfer and recidivation. But antineoplastic drugs could injure normal histiocytes under normal therapeutic dose, especial for active spermatogenic cells, antineoplastic drugs not only resulted in acute damage for them, but also resulted in azoospermia and oligospermia, then affected seminiferous function, serious patients were even no sperm.A spermatogonia were seminal cells, if A spermatogonia could grow and mature normally, which resulted in normal seminiferous function. However, previous researches mostly concentrated damage that antineoplastic drugs affected seminiferous function of adults, the research that antineoplastic drugs affected seminiferous function of young children were few.So, It was an especially important research that antineoplastic drugs injured A spermatogonia from headwaters and its mechanisms, which offered an important key and experentmental evidence offered for latter research that protected seminiferous function in chemotherapy.