The Study Of The Function Of Platelet Collagen Receptor GPIa/IIa And GPIV

Thrombogenesis is not only an important pathogenesis factor of thromboembolic disease (such as coronary atherosclerotic heart disease, atherosclerotic thrombotic cerebral infarction, et al), but also an inevitable problem in other type of disease or the course of diagnosis and therapy (such as diabetes, nephritic syndrome, surgery operation, et al). Platelet is a pivotal factor in the course of hemostasis and thrombosis under the physiological or pathological conditions. Collagen, existing in the extracellular matrix under the endothelial cell, is a type of protein constituent that is closely correlative with hemostasis and thrombosis. The interaction of platelet and collagen is the crucial factor to start up the course of thrombogenesis. Many types of active substance are released or generated during the course of the interaction, which play an important role in triggering and regulating a series of reactions in thrombogenesis subsequently. To elucidate the functions of collagen receptors on platelet is the first content of research related to platelet-collagen interaction. All of platelet collagen receptors are glycoprotein on the surface of platelet membrane, which mediate the adhesion between platelet and collagen and...