Experimental Study Of Naringin-Induced Human Bone Marrow Mesenchymal Stem Cells Differentiating Into Osteoblasts

Bone fracture late healed (LH) , disunion, defect and osteoporosis are common clinical problems, which always puzzles orthopedists. Recently, the modern osseous tissue engineering develops very fast, can provide consistent biological pathways to solve these tough problems. How to obtain, cultivate and differentiate the tissue seed cells is its hypothesis and foundation. Because of its powerful proliferation ability and multidirection lineal differentiation ability in vitro, hBMSCs (human bone marrow mesenchymal stem cells) have been obtained as the tissue seed cells. HBMSCs can be cultured in vitro, implanted in animals ossified and drawn-off small amounts from the marrow, that need not suffer second wound, so utilizing the hBMSCs as seeds is the spotlight of the morden osseous tissue engineering. How to utilize inductors, that is the main topic. Recently, the Traditional Chinese Medicine is playing a key role on the topic. Fortune's drynaria rhizome can promote ossification, so it is a good medicine for curing fractures and wounds Ab antiquo The sorts and ingredients of Fortune's drynaria rhizome are complex, so we choicedNaringin-the effective ingredients of Fortune's drynaria rhizome s as an inductor to study the mechanism. Can Naringin induce hBMSCs differentiating into osteoblasts and osteocyties? How to promote ossification?...