Changes Of MGMT, XPC, POLβ And P53 In Esophageal Precancerous And Cancerous Lesions From The Patients At High-incidence Area In Henan

BackgroundEsophageal carcinoma (EC) is one of the most common malignant diseases worldwide with a sharp variation in its geographic distribution. The ratio in incidence between high- and low-risk areas could be as great as 500:1. The high incidence in special areas indicates the importance of environmental factors in esophageal carcinogenesis. Linzhou in Henan is one of the highest incidence and mortality areas for EC in China and in the world. Through mass survey and follow-up study for the past fifty years, it has been recognized that esophageal carcinogenesis is a multistage and progressive process involved by multiple genetic changes and risk factors. It is important for cell carcinogenesis that a series of changes of genes resulted from DNA damage of normal cells. The highly protective cellular DNA repair system could...