Deletion, Methylation And Protein Expression Of P16 Gene In Esophageal Carcinogenesis Of The Same Patient And Its Effects On Prolixferation Of Esophageal Cell Lines

BackgroundEsophageal cancer (EC) is one of the sixth most common malignant diseases in the world with a remarkable geographical distribution. Linzhou city (formerly Linxian) and nearby counties in Henan province have been well recognized as the highest incidence area for EC in the world. Prognosis for EC is very poor and the five-year survival rate is only about 10% for the patients at late or advanced stage. However, the five-year survival rate for early EC patients could be as high as 90%. Obviously, early detection for EC is the bottlenecks in improving the curative rate of EC.Recent results from our laboratory and others suggest that accumulation and/or synergetic effect of multiple genetic alternations contributing to multistage carcinogensis of EC. Alterations of tumor suppressor p53-Rb pathway (including p53, Rb, p16, p14) have been demonstrated as the most common molecular events occurred during esophageal multistage carcinogensis, suggesting that alterations of...