Experiment On Radiation Injury Of The Brain And Its Prevention And Treatment With Traditional Chinese Medicine Of Destagnation And Bushen 978-1

EXPERIMENT 1 Objective To study the regularity of the injury of the mice learning and memory ability, after the whole brain irradiation. Method After anaesthetized with thiopentone, the whole brain of Kunming mice was irradiated with 10MeV electron beam. Mouse learning and memory ability were measured with step down method on the first, second, third, fourth, fifth, fourteenth, twenty-eighth, fifty-sixth and eighty-fourth day after the irradiation. Results Mean number of errors of the mice were 1±0.3, 0.9 ± 0.6 and 1.4±1.0 respectively, all of them were different significantly compared with control on the second, third and fifty-sixth day after the brain irradiated with 20Gy electron beam. In those days, the median latencies of the mice to step down were 64 ±87s, 92 ±78s and 164 ±88s, all of them were shorter than that of the control. On the fourth, fifth, fourteenth, twenty-eighth and eight-fourth day after the irradiation, the mean number of errors and the median latencies of the mice to step down were not different from the control. The learning and memory ability of mice after 20Gy irradiation is injured apparently, that of 10Gy irradiation injured also, but that of 5Gy irradiation was not different from the control. Conclusion Memory ability of the mice is apparently injured on the second, third day after the...