| ABP(3-n-butyl-6-aminophthalide) is a synthetic derivative of 3-n-butylpathalide(Ag-l) isolated from the seeds of Apium graveolens linn. The juice of Apium leaf has long been used for treatment of epilepsy in folk medicine in China. According to recent observation of pharmacology and clinical studies, ABP was found to have anticonvulsive effect, especially for antagonizing maximum electric shock in mice, its effective dosage was only 1/10 the dose of Ag-1.In view of the many similar pathogenesis between ischemical brain injury and epilepsy, and ABP has the major structure of Ag-1 which had been reported to have anticerebral ischemia effect. A study was carried out for observing the effect of ABP on cerebral ischemia with comparing to Ag-1 in many aspect, and elucidating their mechanisms of action in both in vitro, in vivo system as well as in gene level.Today, there is a increasing incidence of cerebral vascular diseases with aging. Among them ischemic event is more popular than haemorrhagia one, especially for the middle cerebral artery occlusion , a kind of ischemical brain disease, characterized by leaving over varied obstacles in speaking, motion and sense with the changes of intelligence and emotion. It was great painful to patients and a big burden to family and society. But present medical treatment for these diseases is poor, no any real effective drug was recognized. Thus, it is a urgent task for us to look for a better preventive or / and treatable drugs.In the present study, the model of middle cerebral artery occlusion in rats, a kind of focal cerebral ischemia, was chosen to evaluate antiischemic effect of ABP...
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