| Insulin resistance(IR) means the target organs, the organizations which the Ins affects biological effect reactivity reduces or loses a series of pathology and the clinical manifestation which but produces.The massive research indicated that,IR passes through in type 2 diabeteses has been developing in process, is type 2 diabeteses dominant characters.Moreover, IR also is the common foundation of causing many kinds of diseases (including hypertension,coronary heart disease,obesity and so on diseases).Therefore in recent years IR has always been a hot spot on medicine field research.The modern research consider that the cell level flaw and the molecular level flaw is the main reason of causing type 2 diabeteses IR. The cell level flaw includes:the function flaw of Liver cell,muscle cell and fatty cell.The molecular level flaw includes the flaw of acceptor,forwards acceptor and backward acceptor.And some research consider that the obesity is the important factor of causing IR.In type 2 diabeteses, obesity participates in the mechanism of IR, either for independently causing,or aggravates IR with type 2 diabeteses synergism.The mechanism of obesity affect type 2 diabeteses which related to thefat distribution-----the internal organs abdomen. The high fatdiet may cause IR, regardless of the animal either the human eats high fat meals for a short-term or a long time will cause IR, and IR is independent in the weight gain and the body fat distribution as well.Many cell factors also participated in IR.This topic on spleen weakness blood stasis argument is related to understanding of the TCM of XiaoKe(Tang Rongchuan );as well as modern medicine aboutspleen and pancreas physiology function explanation[4];and the explaination of the mechanism of IR by modern medicine .The experiment adds STZ and the high fat feed to assist the induction IR of the big mouse pattern, makes the comparison by DMBG,observed Reducing the Sugar to Decrease the Fat Soup to the improvement function of IR in mouse at early time;At the same time observed Reducing the Sugar to Decrease the Fat Soup to the mouse pancreatic gland organizational structure and the liver cell membrane InsR immunity histochemi'stry influence;By RT-PCR examination of skeletal muscle organization GLUT4 mRNA and the liver InsR mRNA expression. From the molecular level to discussion about The Reducing Sugar to Decrease Fat Tang to improve IR action mechanism.The discovcris indicate that The Reducing the Sugar to Decrease the Fat Soup can possibly propose the big mouse insulin sensitivity;Reducing the blood platelet gathering rate;losing weight;as a result surrendering to the state big mouse skeletal muscle GLUT4 mRNA and the liver InsR mRNA expression;finally producicng a kind of protective function to the big mouse pancreatic gland organization internal secretion gland and the exocrine gland.We speculate The Reducing the Sugar to Decrease the Fat Soup can be with the improvement in acceptor function and backward acceptor function for type 2 diabeteses IR big mouse. |
PDF Full Text Request