The Expermental Study Of The Pathogenesis And Diagnosis Of The Early Stage And Prevent Treatment Of Steroid-induced Femoral Head Osteonecrosis Of Rabbits

Objective.Osteonecrosis of the femoral head(ONFH)is a disable and pregressive condition and, if untreated,leads to femoral head collapse requiring total hip replacement.Because hip-preserving threapies are most effective in the earliest stages of ONFH),the key to successful treatment lies in identifying at-risk population and quantifmg their risk in terms of clinical and pathophsiological characteristics so that early diagnosis be made before head collapse.Currently critical gaps exists in our understand of clinical features and pathophysiology of ON that have direct bearing upon our ability to intervene threapeutically for hip preservation. At present, some studies have suggestd that hypercoagulability,specifically thrombophilia and hypofibrinolysis,play an important role in the pathogenesis ONFH,contemporary studies of the pathogenesis of ONFH have focused on the vulnerable microcirculation of the femoral head and the ischemic consequence of microvascular thrombosis(occlusion).At the same time,a...