The Study Of Effects And Molecular Mechanism Of Defensin On The Pathogenesis Of Inflammatory Bowel Disease

ObjectivesInflammatory bowel diseases (IBD) include ulcerative colitis(UC) and Crohn disease(CD), which have progressively increased in the last 20 years in China. Despite active research for many decades the etiology and pathogenesis of IBD is still enigmatic. Most of research suggested possibilities include genetic, environmental, immunologic, and infectious causes, but still unsuccess in finding the aetiological culprit. The gastrointestinal tract is exposed constantly to an abundant amount of commensal bacteria with some potential pathogens. The innate, immune system of mucosa plays a central role in preventing intestinal microbes from intestinal column to the wall. It has been confirmed that intestinal epithelia produce an series of immune effector molecules such as defensins to resist against bacteria and other microbies, or with signal transferring to trigger adaptive immune response resulting in protective response for intestinal mucosa. Recently, it has been speculated that IBD originates from an alteration in mucosal defensins, in which β-defensin-2 is very important. Many studies have found that expression of β-defensin-2 increased in intestinal epithelia by infection and...