Compressed Oxygen In Drug Stability Experiments And Evaluation Of Antioxidants Using Oxidation Reaction Rate Constants

Section One: Compressed Oxygen in Drug Stability ExperimentsIn oxido-stability studies, some drugs are unstable to oxygen, indicating that their stabilities depend mainly on the pressure of oxygen (or the concentration of dissolved oxygen in solutions). The drugs that are unstable to both oxygen and heat should obviously depend on both the pressure of oxygen and the storage temperature. In order to predict and improve the stability of these drugs, it is important to study their oxidation rates. But a study of such phenomena has not been found in the literature, except that some drugs are unstable (or stable) under an aerobic (or anaerobic) condition.A drug stability experiment accelerated by compressed oxygen was established. The stability of 10% ascorbic acid solution as a model was studied and the kinetic parameters were obtained with the newly established experimental method. Because ascorbic acid degrades under both anaerobic and aerobic conditions, the...