Anti-nasopharyngeal Carcinoma Effect In Vitro And In Vivo Of LMP2A-specific Cytotoxicity T Lymphocyte Induced By Dendritic Cells

Nasopharyngeal carcinoma (NPC) is a malignant tumor derived from the epithelial cells and occurs mainly in the Southeast Asia and South of China. NPC is usually difficult to be removed by surgery. Although radiotherapeutic and chemotherapeutic methods are effective for NPC, they could not eliminate tumor cells completely, especially those in circulatory systems and metastatic focuses. The immunologic function of the patients could also be damaged by these conventional methods during treatment. Relapse and metastasis of tumor occur usually in some NPC cases. Therefore, it is critically important to develop an immuno-therapeutic method for NPC.It has been demonstrated that the cellular immunity, especially cytotoxic T cells (CTL) response, plays an important role in the immune response against tumor. Antigen presentation is critical for the initiation of adoptive immune responses. Dendritic cells (DC) are known as the most powerful and the only antigen-presenting cells (APC), which are capable of activating naive T cells and initiating primary immune response. More and more studies prove that DC pulsed with various...