The Study On The Electrophysiological Results And Their Related Factors In Myasthenia Gravis

Myasthenia gravis (MG) is an acquired autoimmune disease which affects severely the patient's work ability and even causes death. Fortunately the disease can be well managed with effective immunomodulating therapies. So confirming a diagnosis of MG is extraordinary important. The electrophysiological tests are very valuable in confirming the clinical diagnosis of MG. In order to recognize more fully the diagnostic value of electrophysiological tests in MG, to investigate the effects of pharmacological agents and thymectomy on them and give more introductions to clinical works, this topic performed a series of prospective research works on electrophysiological results and their related factors in MG patients.The research works include four parts, each focusing on the direct comparison of single fiber electromyography (SFEMG) and repetitive nerve stimulation (RNS) of the same extensor digitorum communis (EDC) muscle, the correlation between clinical absolute scores and electrophysiological results, effects of cholinesterase inhibitors on the results of SFEMG and RNS, the changes of electrophysiological parameters and clinical scores before and after thymectomy in MG patients respectively.