Study On The Effects Of Repetitive Transcranial Magnetic Stimulation (rTMS) On The Middle Cerebral Artery Occlusion Reperfusion Injury Model Of Wistar Rats

Background and purpose: The treatment and rehabilitation strategies for ischemic stroke have been the attention focus of many neurological scientists for a long time. At the basis of the principle of the electromagnetic induction, transcranial magnetic stimulation (TMS) firstly used in 1985 could evoke electrical current in cortical neurons by time-varying magnetic field stimulation. This electrical current can conduct down to the target muscle along with the pyramidal tract, and arise a motor evoked potential (MEP). As a new non-invasive and good tolerance technique, the volunteers and the patients can accept TMS easily. TMS can provide some electricalphysiological characteristics information after ischemic stroke, which involved motor threshold (MT), MEP and so on, is correlated with the prognosis and have arisen extensively attention in multiple fields, such as the public medicine, the psychological and neurological scientists. Repetitive transcranial magnetic stimulation (rTMS) occurred in the last decade. It is the development of single pulse TMS, can produce trains of magnetic stimulation with certain intensity and frequency, and affect the functional state of the local stimulus and remote sites, involving the changes of neurotransmitter, regional cerebral blood, and the state of brain metabolism. The different combination of parameters, such as frequency or intensity, will cause different influences; low frequency will reduce the local blood supply and the metabolism rate, while high frequency will act otherwise, then the primary balance between the inhibition and the excitability level of cortical neurons will be changed, resulting series of secondary influence. People have noticed its specific improvement on major depression or other dyskinesia diseases. RTMS has been widely used in various research and treatment fields as its specific characteristics of no pain, no-invasive, safe and good tolerance. In Canada and Israel, it has been a routine treatment alternative for the major depression. But little is known about whether rTMS could affect the pathophysiological conditions of ischemic stroke, and whether it could protect the ischemic neurons. The present study demonstrates the influence of rTMS on the motor cortical excitability and neurofunction at...