The Research Of The Effect Of Human Peripheral Blood Mononuclear Cells And Endothelin-1 On Human Periodontal Ligament Fibroblast

The basic procedure of orthodontic treatment is tooth movement resulted from periodontal tissue biological response and remodeling induced by mechanical forces. The periodontal vascular system changes when orthodontic therapeutic mechanical stress is applied to the teeth. Some researches showed that the vascular changes preceded the deposition or resorption of bone. These vascular changes seemed to contribute to the regeneration of the periodontal membrane. The results showed that periodontal vascular system plays an important role in the reconstruction of periodontal tissues during orthodontic tooth movement.Periodontal ligament fibroblasts are the predominant cell type in the PDL. They have additional specialized functions and are considered responsible not only for the formation and maintenance of the PDL but also for the repair, remodelling and regeneration of the adjacent alveolar bone and cementum.