A Research For The Determination Of The Integration Sites Of Human Papillomavirus Transforming Genes In Chromosomes Of Cervical Carcinoma Cells And Their Significance In Cervical Carcinogenesis

Human squamous cell carcinoma of uterine cervix (cervical carcinoma) is one of the most common cancer among all malignant diseases in Chinese women. On past decades, through clinical, epidemiological, pathological, molecular and cellular biological and tumor virological studies, human papillomaviruses (HPVs) are considered as the leading cause of cervical carcinoma. HPVs has a high infectious rate in cervical carcinoma, they can promote the proliferation of normal cervical epithelial cells, immortalize some kinds of cell in vitro and malignantly transform these cells together with other cofactors, such as c-myc protooncogene, mutant p53 suppresser gene etc, as shown in this lab.Among about 100 types of HPVs up-to- date isolated and characterized, more than 20 types are related to the diseases of human urinogenital tracts. HPVs can be further classified as either "Low risk" or "high risk" based on whether or not the genital lesions with the risk for...