Experimental Studies Of MaxEPA On Heart Allograft Survival, Its Immunological Mechanism And Protective Effect Of MaxEPA Against Cyclosporine A Induced Toxicities.

Experimental studies of MaxEPA on heart allograftsurvival, its immunological mechanism and protectiveeffect of MaxEPA against cyclosporine A induced toxicities.Lou doner hearts were transplanted heterotopically into the necks of Fisher recipients with standard microvascular techniques to observe the effect of MaxEPA (Eicosapentaenoic acid) on graft survival. Daily administration of MaxEPA(equivalent to EPA 300mg/kg) P.O. to recipients from 3 weeks before transplantation prolonged the graft survival time by 59% compared with control, suggesting that MaxEPA could provide a mild anti-rejection effect.Further studies were made of effects of MaxEPA on immune system in normal C57BL mice after MaxEPA ingestion of the same dosage for 3 weeks, by spleen cells assayed for the ability to produce interleukin 2(IL-2);respond to concanavalin A (ConA)or lipopolysaccharide (LPS) stimulation and their natural killer (NK)cell activity, and also by measurement of antibody production . Data showed that MaxEPA caused an inhibitory effect on IL-2...