Study Of Plasma Levels Of Aβ1-42, Aβ1-40, And Tau In Alzheimer Disease

Alzheimer disease (AD) is a neurodegenerative disease that accompany specifictic pathology and biochemical alter, it cause progressive cognitive, ability of life and behavior deterioration, irritation and epilepsy may appear in the severe patients, that bring serious burden for family and society. Besides cardiovascular disease, cancer and stroke, AD has now become the fourth major cause of death, and is attented in the world. After longitudinal study, some cholinesterase inhibitors have been found useful in improving the cognitive functions in some mild patients, it is the key to achieve early clinical diagnosis of AD so that more effective therapy can be started earlier in the course of AD. In clinical practice, there are no specific biochemical markers for the diagnosis of A D; c urrent c riteria for t he diagnosis o f A D a re s till largely based on psychiatric test, which are difficult at differentiation from 'aging-associated cognitive decline' and from other relevant forms of dementia. Affected brains of AD patients are characterized by the presence of senile plaques (SP) and neurofibrillary tangles (NFT), senile plaques are mainly composed...