Experimental Study Of The Action And Mechanism To Rheumatoid Arthritis And Compatibility Of Dangguiniantong Tang

Rheumatoid arthritis (RA) is one of serious chronic diseases which threat public healthy in the world, the mechanism of outbreak is complicated. Dangguiniantong tang had a good effect to treat RA. This reseach carry on a deep study on anti-inflammation, immunity and treatment mechanism to RA of Dangguiniantong tang. By the decomposition and compatibility study, explored the meaning of juanbi method and fuzheng method in Dangguiniantong tang.Objective: study the mechanism of Dangguiniantong tang treat RA and the meaning of compatibility.Methods: take adjuvant induced arthritis rat as experiment model, treat with Dangguiniantong tang, each decomposition and TriPterygium Glycosides in different groups. Observe the swelling of arthritis, press-risisting index, thymus, spleen index , pathology change in arthritis, and the express of CK, ICAM-1, IL-1, VEGF, MMP, Fas/FasL mRNA, explore the anti-inflammation, immunity and partial treatment mechanism to RA of Dangguiniantong tang and it's decomposition.Results: (1)Dangguiniantong tang has obviously effect of anti-inflammation, inhibition swelling of arthritis, increase the perss-resisting index, it can also lighten the synovial inflammation and hyperplasia of lesion joints distinctly, and prevent the joint cartilage and bone from destruction. (2)Dangguiniantong tang can retain the excessive decimrter of TNF- a, IL-1, improve the immunity function of RBC, so as to give play to anti-inflammation and immunity adjust. Juanbi method has good effect on anti-inflammation and fuzheng method has good effect at immunity adjust. (3) in locat joints, Dangguiniantong tang can retain the excessive express of ICAM-1, thus retain the inflammation andproliferation of synovial tissue. (4).Dangguiniantong tang can decrease the express of VEGF in synovial tissue, drcrease the growth of new vessel, retain the form of pannus. (5) Dangguiniantong tang can decrease the express of MMP-3 in synocial tissue, prevent the destroy of bone and cartilage. (6) Dangguiniantong tang can increase the express of Fas/FasL mRNA, improve the disorder of PDD.Conclusions: Dangguiniantong tang has the effect of anti-inflammation and immunity adjust, they are related with inhibite expression of inflammation CK and improve the immunity function of RBC. By the way of adjusting the express of MMP-3, Fas/FasL mRNA, VEGF, ICAM-1 in synocial tissue, Dangguiniantong tang control the inflammation of synocial, and prevent the distory of bone and cartilage. Juanbi method has good effect at anti-inflammation, and fuzheng method has good effect at immunity adjust, they have good compatibility effect in whole prescribe.