Changes On AMPA Receptors And Related Protein In Immobilization Stress Rat And Its Relations With Liver Function Of Smoothing Qi Flow

Stress is a series of neuroendocrine responses which is marked with sympathetic nerves excitement and increase of pituitary -adrenal gland cortex secretion when organisms is expose to various factors (stress factor) stimulation. It has great significance for biological survival. Appropriate stress response is benefit to individual improvement in adaptability to environment changes, but excessive, especially chronic stress, causes physical, psychological disorders in vary degrees, and even causes body diseases. Since chronic stress is an important factor in many diseases course, and directly related to the state of sub-health, there are a large number of researchers studying on it since 1980s. Several systems involves in stress response, different stressor, different individuals and different circumstances might lead to different results, this is difficult for the prevention and treatment of stress diseases, and Chinese medicine, as a mathod of whole adjustment, treatment based on different syndromes and individualized diagnosis, has shown greater superiority. This project was supported by National Science Foundation Committee of China(310000216), and we focus on the theoretical study and experimental study on the central neural system mechanisms of stress response and the role of regulation function of liver governs smoothing qi flow(LGSQF) in stress response, the result as the following:1 Theoretical StudyLGSQF is the core of liver physiological functions, which disorder lead to diseases in vary range, and stagnancy of liver-qi, disorder of qi activity are the basic pathological mechanism. Base on information control system theory and analysis retrospectively, we suggest the foundation physiology of LGSQF as follows : Instinctive demand of the body is the core of the liver governs smoothing qi flow; Limbic system, the center of motivation and emotion, is the regulation and control center of LGSQF; Hypothalamic- brain stem- autonomic nerve pathway and sympathetico-adrenomedullary system pathway are information pathways; Smooth muscle system is the effective appararus of LGSQF, which realizes the changes of distribution of qi, blood and body fluids by relaxation and constriction of smooth muscle to carry out liver's function, and transmit this changes to limbic system for feedback regulation through sensory nerve system; And the adrenal cortical hormone play a role in maintaining a normal level and changes.Five zang-organs are involved in stress response, but heart, liver and kidney in them are the most important. In the course of stress response, the heart is in charge of the formation of sensation and perception, makes decision after cognitive appraisal, and then transmits the decision to subcortical center; it processes the feedback of the internal organs and the body; and it also is regulated by adrenal cortical hormone. Liver, that receives the decision from heart, forms emotion in limbic system and acts on locus coeruleus- norepinephrine/...