Construction Of Digitized Anatomical Model And Visualization Of Human Cerebrum

Visible human technique was used to collect human cerebrum data. After semi-automated segmented on the serial cross-sectional image data with Photoshop software, the main structures of cerebrum were reconstructed and visualized on personal computer by using the software for tridimensional reconstruction exploited by our research group and the VR software provided by the Chinese University of Hong Kong. The tridimensional coordinate system was established on the midpoint of intercomissural distance. The main structures of cerebrum were localized and measured in the 3D space. The transverse, coronal and sagittal sectioning images of cerebrum were compared with magnetic resonance images. The main results demonstrated in the present study are as following:1. Visible human technique was improved and used to obtain cerebrum data sets of Chinese visible human. The resolution of cross-sectional image reaches to 11 000 000pixels(4064×2704) and thickness of each cross section at 0.1mm. The data file of each section occupies 63MB.2. Semi-automated segmentation and Photoshop software were selected to segment cerebral cortex, white mater, basal nuclei, lateral ventricle and hippocampus et al. On personal computer, the segmented structures were reconstructed in three-dimensions with volume rendering reconstruction and surface rendering reconstruction. The reconstructed structures can be displayed singly, in small groups or as a whole and can be continuously rotated in 3D space at different velocities. Any diameter and angle of the structures can be conveniently measured.3. Seven anatomical atlas of thin serial section images of cerebrum were obtained, including five transverse sections, one coronal and one sagittal section. This material provided an accurate detail of anatomical basis neurosurgery and clinical imaging diagnosis. Two accurately segmented images of cerebrum were completed.4. The thin sectional images of cerebrum were compared with MRI and acquired the sectional and imaging features of cerebral sulci, gyri and main structures in transverse, coronal and sagittal planes, which can provide sectional anatomic data for MRI localization of cerebral local lesions and imaging study of brain function. 5. On tri-dimensional model of cerebrum, the tri-dimensional coordinate system was established on the midpoint of intercomissural distance. The volume and ratio of cerebral cortex, white matter, basal nuclei, lateral vernticle and hippocampus were measured. And the localization of the main structures of cerebrum in 3D space was obtained.6. A three-dimensional digitized anatomical model of human cerebrum was established. The user interface for navigation of the model was developed by VTK tool. Each element of the model is associated with a name tag and the model has tridemensional coordinate system on the midpoint of intercomissural distance, often used in clinic. Which made the model can be used for visualization in surgical planning, for model driven segmentation and for the teaching of neuroanatomy.7. With the aid of a graphics accelerator and advance visualization techniques developed by our research team, real-time visualization of the cerebrum data set became feasible in a 3D virtual environment. The 3D reconstruction of cerebrum slices can be stereoscopically viewed. We can also rotate the 3D images around any spatial axis and of section them in any orientation. Based on initial transverse sectional images, we can display sagittal, coronal, and other directional sections of cerebrum by computerized 3D reconstruction.