| Skin photoaging is believed to account for the vast majority of the skin's age-related psychogenic pressure as well as cosmetic. Of even greater concern is the risk for skin cancer. The molecular mechanisms of photodamage by ultraviolet are poorly understood. Until now, there are few reports on the study and treatment of photoaged skin in China. For many decades, chemical peeling has played an important role in facial rejuvenation and still be used as a common tool for the cosmetic surgeon to treat photoaging skin in abroad. Among multiple chemical peeling formulas, Baker's formulas are the most effectively in common use .The main ingredients of that are phenol and croton oil. Although Baker's formulas have been used for many years and produced a surprised effection in photoaged skin, the mechanism remains unclear. There are a lot of arguments on it.The collagen is main component in dermis, it is about 70% net weight of dermis . The collagen is important to maintain cutaneous filling, tension and elasticity. The dermal collagen is mainly composed of type I and III collagen which secreted by fibroblast.In our study, the hairless mice was irradiated under UVA, UVB and the combination of the two. The UV-induced changes in these mice were very similar to those in human photoaged skin. After then, the phenol and croton oil chemical peeling agents were used to the UVA/B-irradiated skin of hairless mice and untreated group as controls. Our results showed that the treated areas of irradiated skin recovered rejuvenation and exhibited a unique connective tissue layer composed of fine collagen fibers beneath the epidermis. At the same tune, we found that the levels of type I and III procollagen in cells were increased after the fibroblast was treated with phenol or the mixture of phenol-croton oil. Our results suggested that the phenol may play an important role in Baker formula.Our results will be of great help to promote the use of chemical peeling in facial rejuvenation. |
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