| Scar is the inevitable production of tissue repair, and it is gradually developed from granulation tissue. Scar is mainly made up of fiber tissue with a few blood vessels collagenous fibers undergo hyaline degeneration. According to its morphologic change, scar can be divided into two groups --- common scar and pathologic scar. And pathologic scar mainly includes hypertrophic scar and keloid. According to its development, scar can be defined as actively growing scar and relatively resting scar . The major features of actively growing scar are: the high multiplication rate of fibroblast and the high apoptosis rate, and strong collagen secretion. And there are many blood vessels vertical to epithelium in the actively growing scar. While in the relatively resting scar, blood vessels are generally sclerosis and blocked and small blood vessels, appendages of skin and structure of fibroblast mainly disappear. And the relatively resting scar is mainly made up of the collagenous fibers undergo hyaline degeneration. By far, there is any perfect explanation of the development of scar, and since among scars there are different development and transformation, the study on the multiplication and transformation among scars becomes a way to the study on the features of scars.In the past, the study on scars focused on the following aspects: 1. growing, multiplying and apoptosis characters of fibroblast in or fromscar and relation with ECM. 2. the development and transformation of ECM and relation with other related factors. 3. signal transfer passage of related cells and effects on induction, occurrence and development of different scars on genetic level.Previous study emphasizes the multiplying period of scar, in which the cellular number in scar is large, cells are active and the related factors are complex. All these not only provide opportunity but increase difficulty and cost of research as well. In practice, we notice that not all relatively resting scars are stable and unchangeable. By certain stimulating factors, they will still regain the activity of multiplication and secretion. So far there is no report on the research of the relatively resting scar in China, and rare reports abroad. Through the study on the relatively resting pathologic scars, we attempt to find their potentials to multiply and apoptosis in the relatively resting period and this is a new way to show the features of pathological scar.Owing to the features of relatively resting scars, in this period scars mainly made up of collagenous fibers are relatively stable, the number of cells is small, the biological activity such as multiplication decreases. As to their research, we conducted immunohistochemical determination of antigen to express antigen. We gained some results by the different expression of antigens influencing multiplication and apoptosis of relatively resting pathologic scars.1. We determined the research object under the microscope by regular pathological staining, and chose the pathologically relatively resting scars as the experimental samples and determined the possible factors affecting the transformation of relatively resting scars,namely the small blood vessels remaining in the skin and fibroblasts with multiplying activity around appendages of skin. At the same time, we found hyperplastic scar and keloid had the different morphologic features of collagenous fibers under microscope, that is hyperplastic scar always has loose, whirl-like and nodular structure, while keloid has relatively parallel and homogeneous structure. Hyaline degeneration significantly characterizes hyperplastic scar and keloid.2. We determined the expression distribution of genes Bcl-2 and Bax related to apoptosis in HS in relatively resting period and K. Through the analysis of the expression of different apoptosis antigens, we hoped to find its cellular elements and its potentials. We found the expression intensity and distribution of fibroblast of hyperplastic scar and keloid were different. In hyperplastic scar, expression of Bcl...
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