Clinical And Experimental Studies On The Effect Of Anti-HF Of Jiedu Huayu Ⅱ Fang

Hepatic failure is one extremely dangerous clinical syndrome caused by the extensive necrosis of liver cells, or the shap critical harm of liver function test. It is a common result of all liver disease gravis. It is initially considered that etiology and basic pathogenesis of HF were Poisonous pathogen and toxic heat accumulating with phlegm and stagnant blood by HF epidemiological survey accompanied by analysis of literature of TCM. In which noxious heat, blood stasis and phlegm are three pathologic factors of atmost importance. The equivalent basic therapeutic methods of HF are clearing away heat-toxin, dissipating blood stasis and eliminating phlegm. So the fundamental Prescription and drug of HF is Jiedu Huayu II Fang based on the treatment based on differentiation of disease.It is determined that the treatment based on differentiation of disease of HF can heighten clinical curative effect in conrast to the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs of HF by means of the clinical effective observation of Jiedu Huayu II Fang's curing HF. The reality and reliability of the result of HF's etiology anol pathogenesis of TCM are further confirmed through epidemiological survey.It is testified that the curative effect mechanism of Jiedu Huayu II Fang lied in cutting down the level of ETM of HF so as to reduce the necrosis andapoptosis of liver cells by the inducing of ETM, and modifying hepatic encephalopathy and liver micro-circle, in order to reduce the case death rate of HF finally by the conclusion in which Jiedu Huayu II Fang is applied to resist the experimental liver trauma of the HP's rat. It is also convinced that the conclusion of epidemiological survey of HF were scientific knowledge.Western medicine's method of the epidemiological survey is firstly introduced in this thesis in order to approve the etiology and pathogenesis of TCM of HF cases. The effect of Jiedu HuaYu II Fang of treatment based on differentiation of disease takes the lead in curing HF in our country. It is in the lead that the more apparent curing mechanism is applied to explain the effect of the prescription and drug of TCM treatment hepatic failare. It is convinced that treatment based on differentiation of disease is the basic and first factor of determination of treatment based on pathogensis obtained through differentiation of symptoms and signs, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs is the necessary ansummation and addition of treatment based on differentiation of disease in the realm of TCM. The one without the other can lead to the bad effect. Only the combination of the two were able to enhance the level of diagnosis and treatment to open the new realm of TCM.