Correlation Analysis Of Angiotensin Ⅱ And H7N9 Disease And Correlation Analysis Of Phenotype And Genotype In Extreme Environment Of Antarctica

Plasma angiotensin Ⅱ levels are associated with H7N9 disease severity and can predict fatal outcomeA novel influenza A (H7N9) avian origin virus broke out in China since 2013. The mortality rate of H7N9 disease closed to 40%. Facing the highly pathogenic avian origin influenza A virus, it is an urgency of identifying biomarkers to evaluate disease severity and to predict fatal outcome. This study using a series of statistics analysis, found that plasma levels of angiotensin Ⅱ, a major peptide of the renin-angiotensin system (RAS), in patients were significantly higher than in the control groups. The second week of onset the plasma angiotensin Ⅱ levels of critical patients were significantly higher than that of light H7N9 virus infected patients. The level of plasma angiotensin Ⅱ on the second week onset could independent prediction fatal outcome, and the prediction effect was better than c-reactive protein(CRP), oxygenation index(PaO2/FiO2), pneumonia severity index PSI and common clinical markers SMART-COP. This research found the relationship between the H7N9 virus infection patients’ plasma angiotensin Ⅱ levels and disease severity. Plasma levels of angiotensin Ⅱ can predict fatal outcome. Our findings indicate that angiotensin Ⅱ can be a biological marker for lethality avian influenza virus.Plasma angiotensin Ⅱ levels are associated with H7N9 disease severity and can predict fatal outcomeA novel influenza A (H7N9) avian origin virus broke out in China since 2013. The mortality rate of H7N9 disease closed to 40%. Facing the highly pathogenic avian origin influenza A virus, it is an urgency of identifying biomarkers to evaluate disease severity and to predict fatal outcome. This study using a series of statistics analysis, found that plasma levels of angiotensin Ⅱ, a major peptide of the renin-angiotensin system (RAS), in patients were significantly higher than in the control groups. The second week of onset the plasma angiotensin Ⅱ levels of critical patients were significantly higher than that of light H7N9 virus infected patients. The level of plasma angiotensin Ⅱ on the second week onset could independent prediction fatal outcome, and the prediction effect was better than c-reactive protein(CRP), oxygenation index(PaO2/FiO2), pneumonia severity index PSI and common clinical markers SMART-COP. This research found the relationship between the H7N9 virus infection patients’ plasma angiotensin Ⅱ levels and disease severity. Plasma levels of angiotensin Ⅱ can predict fatal outcome. Our findings indicate that angiotensin Ⅱ can be a biological marker for lethality avian influenza virus.Phenotype and gene changes in extremely environment Antarctic ice Dome A correlation analysisAntarctic ice Dome A has extremely environment called the human unreachable pole due to the coldest and driest place on earth,the most distant away from the coastline,and the highest place of Antarctic area. This study collected the Antarctic expediters ’series of physiological and psychological phenotypic index in origin and in extreme environment Antarctic Dome A.And also collected peripheral blood for gene array chip detection. We analyzed 47 changed phenotypic indexes and 1121 difference PPI network gene. The male hormone testosterone changed level had highly linear correlation with tension, depression, anger and fatigue four mood parameters. The bottom GO gene enrichment function results are consistent with the phenotypic correlation results. We did literature mining of the 70 strong associated with four emotions’ PPI network genes, founding 42 genes have the literature in related areas, indicating 28 mood related novel genes. This research provides the reliable method to find phenotypic features related novel genes.