Study Of Huanglianjiedu Decoction Of Its UF Mechanism Based On Analysis Of QSAR,Mass Transfer Model And Kinetics With Model System

The study try using the method of systerm simulation and Chemical Process Control principle in the membrane process research of Chinese herbal decoction. Index composition and various macromolecule materials commonly existed in Chinese herbal decoctions are set up as two types of model systerm and their membrane process are researched separately. Try to explore the establishment of UF transmission rate QSAR models of Chinese herbal index composition and transfer characteristic of macromolecule materials.At the beginning of the research, taking Alkaloids and Iridoid these two kinds of compound in Huanglianjiedu Decoction as the study subject, quantitative structure-property relationships in five membranes are developed by the data mining method of PLS or SVM. It shown from the parameters in the models that the main factors which infect the UF transmission rate are interaction of compound property and membrane property and compound spatial structure.Then taking starch,pectin and protein these three macromolecule materials in Chinese herbal decoctions as the study subject, the mass transfer models of model systerm in seven membranes are formed, the resistances from concent ration polarization were obtained. At the same time kinetics analysis in the ultrafiltration process is studied . The research lays a foundation for the exploring of macromolecule materials transfer mechanism and the substance foudation of membrane fouling, and for the the Optimal Design of ultra-filtration membrane in the production of Chinese drugs preparation.Part three: Examining the adsorption behavior under static condition of the model systerm of three macromolecule materials in seven UF membranes, setting up adsorption models under static condition, and comparing the adsorption characteristic of the three macromolecule in different membranes. The results show that starch,pectin and protein are all have adsorption fouling in three membranes in common use -PS,PES and PVDF. The adsorption under static condition corresponding in character of Langmuir mode, and the adsorption occur in the first 40 minute. The membrane materials have little effect on the adsorption capacity. There is no significant difference of adsorption capacity of starch and pectin in membranes with different MWCOS. But the adsorption capacity of protein increase as the increasing of membrane MWCOS.Finally, On the basis of the above study, the UF process of model systerm of Huanglianjiedu Decoction is researched. Using the membrane flux change,the fouling degree of membrane,the preserving degree and adsorption capacity of efficiency components as guide line, trying to find out the influence of macromolecule materials on small molecules in Huanglianjiedu Decoction. The results show that the two small molecules berberine and gardenoside in Huanglianjiedu Decoction have high permeation rate. But for the reasons of interaction of macromolecule materials and small molecules and forming of concentration layer and gel layer, the permeation rate of small molecules reduces greatly. Starch and pectin are the two main macromolecule materials in Huanglianjiedu Decoction which cause membrane fouling and flux falling.The innovations of this article lie in the following two ways: Firstly, using QSAR and data mining method in the mechanism research of UF technique in Chinese herbal decoction for the first time. Models of quantitative structure-property relationships of effective compounds in Chinese medicine with five membranes are initially developed. Improving the research of UF technology in Chinese herbal decoction to a microcosmic and quantitative level. Secondly, research systematically macromolecule materials commonly existed in Chinese herbal decoctions for the first time, and develop mass transfer models,kinetics models and adsorption models under static condition of starch,pectin and protein. The research lays a foundation for the exploring of the substance foudation of membrane fouling, and for the the optimal design of membrane technology in the production of Chinese drugs preparation.