Studies Of Molecular Probes Based On Dansyl Photosensitizer

Molecular recognition,which is the key concept and basic research field of supramoleclar chemistry,refers to the selectively binding progress between the host and the guest substrate,resulting in the production of special function.Due to their high selectivity and sensitivity,easy and rapid detection,fluorescent probes have been extensively used as cation,anion and small biomolecular sensor;especially the sensor for the anions and small molecular in life system.This paper reports the design and synthesis of fluorescent sensors for cations,proton,and ions or small biomolecules in life system,derived from dansyl sulfonamide fluorophore.1.In this paper,a serious of highly selective fluorescent Zn²⁺ and Cr³⁺ sensor have been prepared by combining the dansyl sulfonamide which act as an effective fluorophore with proper chelating group.By fully investigating the basic and excite properties of the probe and the spectral change during the recognition process through the UV and luminescent spectrum, the high selective recognition toward the Zn(â…¡) and Cr(â…¢) ions in aqueous solution was realized and the low detection limit attached to ppm level.This investigation offers the important data for the further study of detecting the two ions in live cell and organism. Furthermore,a multi-channel receptor composing of two fluorophores of dansyl sulfonamide and naphthyl,have been designed to selective recognition Zn²⁺,Cr³⁺ and Mg²⁺ through the adjustment of the excited wavelength and the concentration of the probe,respectively.2.By combining the dansyl sulfonamide group and 8-hydroxyquioline together,a kind of new qualdentate ligands and a serous of mononuclear or binuclear lanthanide complexes containing TTA(α-Thenoyltrifluoroacetone) as auxiliary ligand have been synthesized.By fully investigating the lanthanide emission progress,the high sensitive fluorescent probes which can response H⁺ concentration on near neutral condition have been reported.At meantime,the advantage of the lanthanide luminescence such as high intensity,narrow line and low background make it possible to use the lanthanide probe in actual practice.It is reported the first time that the pH value was successfully detected by using the characterized near infrared luminescence of specific lanthanide ions.3.Metal-organic calix[3]arenen fashion with stable structure and well photo response properties are assembled by amide group rich muti-dentate ligands and metal ions with suitable coordination geometry.Through the space strict and the positive charge environment of the cage-like host,by introducing the dansyl sulfonamide as fluorophore,the cages can high selectively detect the ATP(adenosine trisphosphate) among the twelve ribonuclotides in aqueous solution,through dual channel response of UV and fluorescent with high sensitivity, exhibiting the advantage of stereoselectivity in these cagelike structures.4.By exploiting the advantage of the metal-organic structure in the stereoselectivity and electro-photo response properties,a serious of calix[3]arenen-like metal-organic trianglar helicates are synthesized and successfully used in the recognition and sensing of GSH in aqueous solution through the co-operation of weak interactions,size and shape selective. Through the fully investigation,it is revealed that the cysteine can take effect on the UVresponse through the weak interaction with the amide group on the "bottom " of the calix[3]arenen,while glutamate can increase the luminescent intensity through the weak interaction with the sulfonamide group.This result provides a simple model for the study of the interaction between GSH and protein in the life system.