Studies On The Molecular Recognition And Related Mechanism Concern With Bridged Bis-cyclodextrins

Cyclodextrins (CDs) and their derivatives are a well-known class of host compounds in supramolecular chemistry. They have unique spatial configuration, showing cylindrical or hollow truncated cone shapes. Their cavities have hydrophobic character, whereas the rims are hydrophilic. These structural features enable cyclodextrin to accommodate diverse hydrophobic organic, inorganic and biological molecule to form host-guest or supramolecular complexes in aqueous solution. CDs have been used extensively as molecular receptors, enzyme mimics and drug carriers in science and technology. Consequently, it would be of great interest to investigate the recognition mechanism of CDs and their derivatives since it can provide valuable information of biological systems.As a new family of cyclodextrin derivatives, bridged cyclodextrin dimers are known to greatly enhance the original molecular binding ability of native cyclodextrins through the cooperative binding of one guest molecule in the closely located two cyclodextrin cavities. Therefore, bridged cyclodextrin dimers are important acceptor not only in the field of molecular...