| Fermentation industries, including the production of alcohol, organic acids, enzyme preparations, antibiotics, starch sugars, amino acids, vitamins, bio-pesticides, plant growth regulators, single cell protein etc. have been extensively developed in China and their application covers the field of medicine, food, chemicals, agriculture, energy resource, environmental protection etc.. The scale of some products such as monosodium glutamate(MSG), citric acid, enzyme preparation and yeast occupies a leading position in the world. They are one of the most important industrials in Chinese economy.Fermentation process monitor and control are an important part in bioprocess engineering. Sensors play a key role in acquiring data from a certain bio-process and keeps on updating a control model. The current sensors have been developed to monitor the parameters of temperature, dissolved oxygen, pH, pressure, viscidity, turbidity conveniently and some of which have been applied successfully to online control and optimization systems in fermentation industries, which is assumed to be fully characterized by a constructed model. However, because of multiple variables, serious nonlinear and multiple work modes, many industrial process are too complex to be described by a model only based on physical parameters. Furthermore, the present models not only reduces the estimate precision but also increases the computational complexity, because there are lack of effective online instrument for efficiently measuring the biochemical information that are essential for the fermentation process control.
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