Effect Of Bushen Cuopai Recipe On IVF Pregnancy Outcomes In Patients With Infertility Due To Kidney Deficienc

Purpose: The purpose of this study was to explore the influence of Bushen Cupai Decoction on IVF-ET pregnancy outcome of infertility patients with kidney deficiency syndrome,and observe the influence of Bushen Cupai Decoction on clinical symptoms,HCG daily serum sex hormone level,Gn dosage,endometrial thickness,number of eggs obtained,number of transplantable embryos,pregnancy status,etc.To provide clinical theoretical support for the application of integrated Chinese and Western medicine in assisted reproductive technology treatment.Materials and Methods:A total of 62 infertility patients with kidney deficiency syndrome who received IVF-ET in line with the natriol standard were randomly divided into control group and treatment group with 31 patients in each group.The control group received IVF-ET treatment alone,and the treatment group was supplemented with Bushen Cupai prescription from Gn initiation day to HCG day on the basis of the control group.The clinical efficacy,TCM syndrome score,dosage of E2,P,LH,Gn,endometrial thickness,number of eggs obtained,number of transmissible embryos,pregnancy rate and other indexes of the two groups before and after treatment were observed.Results:1.Comparison of clinical comprehensive efficacy: The total clinical effective rate of the treatment group and the control group were 90.32% and 67.74%,respectively,and the clinical efficacy of the treatment group was higher than that of the control group,the difference was statistically significant(P < 0.05).2.Comparison of TCM syndrome score: Before treatment,the TCM syndrome score of the treatment group was 14.45 ±2.20 points,and that of the control group was 14.94 ± 1.75 points,which was comparable.After treatment,TCM syndrome score of the treatment group was 7.58±3.66 points,and that of the control group was 10.45±3.02 points.After treatment,TCM syndrome score of the two groups was reduced,and the treatment group was lower than the control group,with statistical significance(P < 0.05).3.Comparison of serum sex hormones on HCG day: After treatment,serum E2 on HCG day in the treatment group was 2714.68(1995.62,3361.00)and that in the control group was2182.91(1587.63,2701.07),which was higher in the treatment group than in the control group,with statistical difference(P < 0.05).After treatment,serum LH on HCG day in the treatment group was 2.04(1.48,3.73)and P was 0.88(0.70,1.08),while that in the control group was 2.46(1.53,5.06)and P was 0.88(0.74,1.12),and there was no statistical difference in the levels of LH and P between the two groups(P > 0.05).4.Comparison of Gn dosage: The amount of Gn in the treatment group was 2100(1800,2250)units,and the amount of Gn in the control group was 2400(2100,2700)units,and the difference was statistically significant(P < 0.05).5.Comparison of intrauterine membrane thickness on HCG day: 10.4(9.4,11.3)mm in the treatment group;The control group was 9.8(9.3,10.3)mm,and the treatment group was better than the control group,with statistical difference(P < 0.05).6.Comparison of the number of eggs harvested: The number of eggs harvested in the treatment group was 12.29 ± 3.42,and that in the control group was 10.68 ± 2.68.The treatment group was superior to the control group,with statistical difference(P < 0.05).7.Comparison of the number of transferable embryos: the number of transferable embryos in the treatment group was 8.03 ± 1.74,and that in the control group was 6.18 ± 1.38.The treatment group was superior to the control group,with statistical difference(P < 0.05).8.Comparison of pregnancy outcomes: 13 patients in the control group had positive urine HCG 14 days after transplantation,and 11 patients had clinical pregnancy(2 patients had biochemical pregnancy),with a clinical pregnancy rate of 35.48%.In the treatment group,19 patients had positive urine HCG 14 days after transplantation,and 19 patients had clinical pregnancy(0 patients had biochemical pregnancy),with a clinical pregnancy rate of 61.29%.The pregnancy rate in the treatment group was higher than that in the control group,with statistical significance(P < 0.05).Conclusion1.Bushen Cupai Decoction can significantly improve TCM syndrome scores and related clinical symptoms of infertility patients with kidney deficiency syndrome;2.Bushen Cupai Decoction can effectively up-regulate estrogen levels and improve ovarian reactivity;3.Bushen Cupai Decoction can reduce the dosage of Gn,increase endometrial thickness and number of eggs obtained,improve embryo quality,and thus improve the clinical pregnancy rate of IVF-ET.