Analysis Of TCM Syndrome Types And Syndrome Elements In Vascular Parkinson's Syndrome And Systematic Evaluation Of The Method Of Tonifying The Kidney And Extinguishing Win

Purpose:By means of frequency statistics and other methods,we obtained the names of high-frequency TCM evidence types,disease location evidence elements,disease nature evidence elements,multiple evidence element combination patterns and basic treatments for vascular parkinsonism to provide reference for clinical identification of this disease.Through a systematic evaluation method,we evaluated the clinical efficacy of the method of tonifying the kidney and quenching the wind combined with conventional Western medicine in the treatment of vascular parkinsonism,and obtained an evidence-based basis for its clinical promotion.Material and method : 1.The literature on the TCM classification of vascular parkinsonism published in various databases from the year of establishment to December 31,2022 was searched,and those that met the requirements were screened.The names of the evidence types involved in the literature were normalized,and then split and obtained the disease site evidence and disease nature evidence.The data were processed using Excel software to obtain the distribution characteristics and combination patterns of the evidence types and elements,and infer the basic treatment methods for vascular parkinsonism.2.Search the Chinese and English databases to obtain a comprehensive list of Chinese herbal medicines for tonifying the kidneys and quenching the wind combined with conventional Western medicine from each database from the date of establishment to December 31,2022.randomized controlled trials of therapeutic approaches for the treatment of vascular parkinsonism,retaining those that met the requirements according to the inclusion and exclusion criteria,and entering the relevant information of those that met the requirements into a worksheet in Excel software.Methodological evaluation of included studies was performed using the Cochrane system’s bias assessment tool.Data operations were performed using Review Manager 5.4.1 software to create forest plots.Inverted funnel plots were plotted where necessary.Sensitivity analyses were performed where necessary.Relevant conclusions were drawn from the results.Results:1.The literature on the TCM classification of vascular parkinsonism contains a total of 37 TCM evidence names,the common evidence names in order are liver and kidney yin deficiency(23times,16.43%),qi and blood deficiency(21 times,15.00%),phlegm and heat moving wind(20times,14.29%),etc.,decomposed to obtain 5 pathological evidence elements and 12 pathological evidence elements,the pathological evidence elements in order are kidney(36times,47.37%),liver(25 times,32.89%),etc.The pathogenic elements were Kidney(36 times,47.37%),Liver(25 times,32.89%),and so on,and the pathogenic elements were Dynamic Wind(53 times,20.46%),Yin Deficiency(42 times,16.22%),Blood Stasis(33 times,12.74%),Phlegm(29 times,11.20%),Qi Deficiency(27 times,10.42%)and Yang Deficiency(26 times,10.04%),in that order.The important pathological features of the disease are the intermingling of deficiency with reality and the deficiency of the root and the symptoms.The most common combination of the two elements is "Qi deficiency + Blood deficiency"(21 times,25.93%)and the most common combination of the three elements is "Liver + Kidney + Yin deficiency"(23times,42.59%).2.A total of 15 randomised controlled trials,including 991 patients,were entered into systematic evaluation,and the combination of kidney tonifying and wind quenching formulae with conventional Western medicine for the treatment of vascular parkinsonism was superior to conventional Western medicine in improving overall efficiency,increasing bilateral middle cerebral artery blood flow velocity and high density lipoprotein cholesterol,and reducing Unified Parkinson’ s Disease Rating scale score,Webster Rating scale score,low density lipoprotein cholesterol and TCM evidence score score therapy.However,due to the relatively low methodological quality of the conforming literature,more high-quality randomised controlled trials are still needed to continue to validate this result.Conclusion:1.The names of the TCM evidence patterns in vascular parkinsonism are complex and varied.After standardisation and disassembly,the two disease site evidence elements and six pathological evidence elements with relatively high frequency can cover most of the identification information of vascular parkinsonism.Evidence-based identification of vascular parkinsonism is more conducive to the standardized and precise treatment of vascular parkinsonism in Chinese medicine.The basic treatment of vascular parkinsonism in TCM is to tonify the kidney and quench the wind.In the process of clinical evidence,we can use the treatment methods of nourishing the liver and kidney to quench the wind,tonifying the kidney to invigorate blood and quench the wind,and tonifying the spleen and kidney to quench the wind to treat this disease.2.The combination of tonifying the kidney and quenching the wind formula with conventional Western medicine in the treatment of vascular parkinsonism is superior to conventional Western medicine in improving the efficacy and related indexes,and has a more reliable safety profile,which is worthy of clinical promotion.