| Purpose: By collecting personal general information on patients with rheumatoid arthritis(RA)and Sjogren’s syndrome(SS)in clinical practice,Clinical symptoms,signs,laboratory tests,TCM differentiation and treatment prescription drugs were analyzed by statistical software to obtain the rules of TCM treatment of RA combined with SS,which pointed out the direction and early for the judgment of RA combined SS Intervene.Methods: The retrospective method was used to count the hospitalization in the Department of Rheumatology of the Affiliated Hospital of Liaoning University of Chinese Medicine from January 2020 to June2022 Case information for RA-SS patients,followed by screening against inclusion requirements and exclusion indicators,first collecting diagnostic data on the case and then using EXCEL The table constructs the patient’s medical record database,and finally uses SPSS 25.0 and SPSS Modeler18.0 to statistically analyze and synthesize the results,and finally determine the research results.Results:1.A total of 2 56 patients were admitted in this experiment,2 cases that did not meet the norms,and the remaining 254 cases were excluded.Among them,there were 2 3males and 2 31 females,with a male-to-female ratio of 1:10.04 and an average age of57.60±10.69 years The average course of disease was 8.091±6.632 years,and the disease population was more common in elderly women.2.The distribution of TCM symptoms is as follows: according to each TCM symptom type,the frequency of occurrence is,from high to low,qi and yin deficiency and blood stasis(28.3%)> Qi and Yin deficiency evidence(18.50%)= phlegm and stasis obstruction evidence(18.50%)> Qi and blood deficiency evidence(9.8%)> humid heat obstruction and blood stasis evidence(7.8%)> liver and kidney insufficiency and blood stasis evidence(5.5%)= liver and kidney insufficiency(5.5%)> cold and wet obstruction and blood stasis evidence(3.1%)> Evidence of damp heat paralysis(2.3%)> cold and wet paralysis(0.3%)3.The length of disease course between regions of TCM differentiation is: phlegm and stasis obstruction> humid heat obstruction and blood stasis> moist heat obstruction> liver and kidney insufficiency and blood stasis > evidence of qi and yin>deficiency of qi and blood> cold and wet obstruction and blood stasis> qi and yin deficiency and blood stasis> cold and wet paralysis > liver and kidney insufficiency.4.Clinical manifestations:(1)Number of swollen joints and The number of tender joints varies Chinese medicine Certificate group Differences have Statistically significant(P<0.05):The TCM types of swollen joints in descending order are: damp heat and blood stasis(17.09)> humid heat and blood stasis(15.96)> qi and yin deficiency and blood stasis(13.20)> cold and wet obstruction and blood stasis(12.60)> liver and kidney insufficiency and blood stasis(12.59)> qi and blood deficiency(12.56)> qi and yin deficiency(12.03)> phlegm and stasis(9.06)> liver and kidney insufficiency(8.50).The number of tender joints in descending order of TCM certificate types were:qi and yin deficiency and blood stasis(18.40)> humid heat and obstruction and blood stasis(15.54)> qi and yin deficiency(14.07)>liver and kidney insufficiency and blood stasis(13.64)> qi and blood deficiency(13.02)> Cold and wet obstruction and blood stasis(12.56)> phlegm and stasis obstruction(11.70)>liver and kidney insufficiency(8.25)> humid heat obstruction(7.62).(2)There were no significant differences in morning stiffness time,number of joint deformities,and DAS28 score among TCM symptom groups(P>0.05).5.Laboratory tests:(1)The CRP indexes were sorted from high to low in TCM symptom type: damp heat and blood stasis(53.22)> humid heat and blood stasis(39.56)> qi and yin deficiency and blood stasis(19.89)> cold and wet obstruction and blood stasis(18.56)> liver and kidney insufficiency(18.43)> evidence of qi and yin deficiency(15.66)>evidence of qi and blood deficiency(15.13)> evidence of liver and kidney insufficiency and blood stasis(11.32)> evidence of phlegm and stasis(10.31)> cold and wet paralysis(1.95).(2)ESR The differences in the indicators were statistically significant between different TCM symptom groups(P<0.05),The levels in descending order are:damp heat paralysis(59.77> Qi and Yin False Evidence(59.00> cold and wet obstruction and blood stasis(56.28> sputum stasis obstruction evidence(45.88>moist heat paralysis and blood stasis evidence(42.70> Qi and Yin deficiency and blood stasis(40.60> liver and kidney insufficiency(40.51> liver and kidney insufficiency and blood stasis(38.02> evidence of qi and blood deficiency(36.42).(3)There were no significant differences in RF,PLT,immunoglobulin Ig G and CCP indexes between TCM symptom groups(P>0.05).(4)Formulas and use of traditional Chinese medicines: A total of 107 formulas were included in this experiment,including 180 flavors of traditional Chinese medicines,with a total frequency of 1578 uses,the highest frequency of use was 78 times,and the lowest was 1 time.Eighteen flavors of traditional Chinese medicines such as North Sand Ginseng and Mai Dong(frequency ≥ 20 times)are all daily medicines for the prevention and treatment of RA combined with SS;Among them,deficiency drugs(yin medicines)accounted for 30.26%,rheumatic drugs accounted for 13.24%,blood circulation and stasis drugs accounted for 12.11%,and antipyretic drugs accounted for 11.78%,and the above four types of drugs were the main categories.6.Cluster analysis was carried out on 1 8 flavor medicinal herbs with a total of ≥ 20 uses,and a total of four clustered drug groups were obtained: class 1,white peony,poria,large belly skin,class 2 Pangolinophyllum,Guizhi,Pork Ling,Dendrobium,Licorice,Class 3 Psyllium,Windproof,Banxia,Sand Ginseng,Class 4,Angelica,Stretch Grass,Mulberry,Tangerine Peel,Mai Dong.7.Drug association analysis results: A total of 98 drug pair and drug group association rules were obtained,including sand ginseng + Maidong(36.000%),sand ginseng + dendrobium(31.000%),white peony + ox knee and angelica and licorice(23.000%).Conclusion:1.Patients with RA and SS have qi and Yin deficiency and blood stasis.2.Patients with dampness-heat obstruction and blood stasis syndrome have frequent joint swelling and frequent pain than patients with other syndrome types.3.The CRP level of patients with dampness-heat obstruction and blood stasis syndrome significantly exceeds that of other syndrome types.4.In addition to the deficiency drugs,dispel wind dampness drugs,blood circulation and heat-clearing drugs are the main categories.5.Cluster analysis of 18 Chinese medicines with 20 times was obtained: class 1,white peony root porkahoe,Class 2,Dendrobium,licorice,Class 4.6.Drug association analysis obtained 98 drug pair and drug group association rules,among which the support rate of sand ginseng + ophiopogon was the highest. |
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