Clinical Observation On Sangdan Tongluo Decoction In The Treatment Of Spastic Paralysis After Cerebral Infarction Of Yin Deficiency And Blood Stasis Typ

Objective:To evaluate the clinical efficacy and safety of Sandan Tongluo Decoction in the treatment of Yin deficiency and blood stasis syndrome of spastic paralysis after cerebral infarction,and to provide evidence for further clinical promotion.Methods:Patients with spastic paralysis after cerebral infarction of Yin deficiency and blood stasis type were selected as the research objects.Randomized controlled clinical trials were designed.MAS score,FMA score,MBI score,NIHSS score and TCM syndrome score table were used to evaluate the degree and efficacy of limb spasm,and the patients were divided into treatment group and control group.The treatment group was given Sandan Tongluo Decoction combined with standardized Western medicine treatment based on guidelines,while the control group was given standardized Western medicine treatment based on guidelines.The treatment course was 4 weeks.MAS score,FMA score,MBI score,NIHSS score and TCM syndrome score table were performed before and after treatment.Blood routine,liver and kidney function,myocardial enzyme routine,blood glucose and lipid,urine routine,stool routine and electrocardiogram were tested before and after treatment to evaluate their safety.Results:1.Comparison of the degree of limb spasm: MAS score was used to evaluate,the control group before and after treatment within the group comparison,the difference was not statistically significant(P > 0.05);the treatment group before and after treatment within the group comparison,the difference was statistically significant(P < 0.05);after treatment between the two groups,the difference was statistically significant(P < 0.05).2.Comparison of limb movement ability: FMA score was used to evaluate,the control group before and after treatment,the difference was statistically significant(P < 0.001);before and after treatment in the treatment group,the difference was statistically significant(P < 0.001);after treatment,the difference between the two groups was statistically significant(P < 0.001).3.Comparison of daily life ability: MBI score was used to evaluate,the control group before and after treatment,the difference was statistically significant(P < 0.001);the treatment group before and after treatment,the difference was statistically significant(P < 0.001);the two groups after treatment,the difference was statistically significant(P < 0.01).4.Comparison of the degree of neurological impairment: NIHSS score was used to evaluate,the control group before and after treatment,the difference was statistically significant(P < 0.001);the treatment group before and after treatment,the difference was statistically significant(P <0.001);the comparison between the two groups after treatment,the difference was statistically significant(P < 0.001).5.Comparison of TCM syndrome efficacy: Before and after treatment,the total effective rate of the treatment group was 82.75%,and the total effective rate of the control group was 50%,the treatment group was higher than the control group,and the difference was statistically significant(P < 0.05).Conclusion:1.Sangdan Tongluo Decoction can improve the clinical symptoms and TCM syndroms of patients with spastic paralysis after cerebral infarction of syndrome of Yin deficiency and blood stasis,with good safety.2.Sandan Tongluo Decoction can improve the symptoms of limb spasm,limb motor function,daily living ability and neurological impairment in patients with spastic paralysis after cerebral infarction of syndrome of Yin deficiency and blood stasis...