Clinical Observation On The Efficacy Of TCM Targeted Drug Therapy In The Treatment Of Depression, Palpitations And Heart Yang Qi Deficiency Typ

ObjectiveTo evaluate the effectiveness of traditional Chinese medicine targeted penetration therapy with antidepressant therapy on heart palpitations sun be the spirit virtual the curative effect of patients with depression.MethodsA total of 44 patients with depression with heart palpitations and heart Yang Qi deficiency admitted to our hospital from January 2020--December 2021 were enrolled as the observation objects.All patients were randomly divided into the control group(22 cases)and the treatment group(22 cases).The former was treated with conventional antidepressant and pseudo-medicine targeted penetration,and the latter was treated with traditional Chinese medicine targeted penetration therapy on the basis of the former.Somatic Selfrating Scale,Hamilton Anxiety Scale and Hamilton Depression Scale(HAMD-17)and TCM Symptom Score Scale were compared between the two groups.Results1.Comparison of demographic data:there is no difference in gender,age,illness duration,education level and occupation between treatment group and control group(P>0.05).2.Efficacy analysis of somatic symptoms in treatment group and control groups:SSS scores decreased at 1-week,2-week and 4-week points from baseline in both treatment group and control group(P<0.05).Analysis of variance of repeated measurements showed significant time effect(F=12.855,P=0.000)significant intergroup effect(F=16.462,P=0.000)and significant time and intergroup interaction effect(F=14.305,P=0.000).Thus,somatic symptoms were improved in both treatment group and control group,as early as at 1-week point,with more improvement in treatment group.3.Efficacy analysis of anxiety symptoms in treatment group and control groups:HAMA scores decreased at 1-week,2-week and 4-week points from baseline in both treatment group and control group(P<0.05).Analysis of variance of repeated measurements showed significant time effect(F=10.063,P=0.000)significant intergroup effect(F=28.547,P=0.000)and significant time and intergroup interaction effect(F=16.078,P=0.000).Thus,anxiety symptoms were improved in both treatment group and control group,as early as at 1-week point,with more improvement in treatment group.4.Efficacy analysis of depressive symptoms in treatment group and control groups:HAMD-17 scores decreased at 1-week,2-week and 4-week points from baseline in both treatment group and control group(P<0.05).Analysis of variance of repeated measurements showed significant time effect(F=13.272,P=0.000),significant intergroup effect(F=14.337,P=0.000)and significant time and intergroup interaction effect(F=13.997,P=0.000).Thus,depressive symptoms were improved in both treatment group and control group,as early as at 1-week point,with more improvement in treatment group.5.Efficacy analysis of TCM symptoms in treatment group and control groups:Scores TCM symptoms score scales decreased at 1-week,2-week and 4-week points from baseline in both treatment group and control group(P<0.05).Analysis of variance of repeated measurements showed significant time effect(F=99.662,P=0.000)significant intergroup effect(F=21.846,P=0.000)and significant time and intergroup interaction effect(F=20.091,P=0.000).Thus,TCM symptoms were improved in both treatment group and control group,as early as at 1-week point,with more improvement in treatment group.Conclusion:1.After 4 weeks of intervention,both the treatment group and the control group improved their symptoms.somatic,anxiety,depression,and traditional Chinese medicine syndrome scores,which basically conforms to the clinical outcome process of Western medicine antidepressant treatment.2.The combination of targeted penetration therapy of TCM and antidepressants can reduce somatic symptoms,as early as 1-week point.Thus,patients respond to this combination much faster than to antidepressants(usually 2-3 weeks).3.Somatic,anxiety,depressive and TCM symptoms in patients with depressive disorders(palpitation-heart Yang-Qi deficiency)get more improvement through the combination of targeted penetration therapy of TCM and antidepressants than antidepressants alone.