| Objective To investigate the effectiveness and safety of micro-plasma in the treatment of hyperplastic post-burn scars in the proliferative phase.Methods Patients who attended the burn unit of Gansu Provincial People’s Hospital from October 2021 to February 2022,were clearly diagnosed with deep II or III degree burns,and were discharged with healed wounds(90% or more wound healing as the criterion for improvement).After sorting by discharge order,the patients were randomly divided by random number table method into scar treatment conventional modality(compression therapy and silicone drugs)combined with micro plasma beam treatment group(Group A)and scar conventional modality treatment group(Group B).Patients with more than 1 burn wound present throughout the body were selected for inclusion using the lottery method.Volunteers in Group A and Group B were instructed to apply topical anti-scar medication and compression therapy as prescribed after wound healing until the 3rd month of scar growth,and were screened again using exclusion criteria at the 3rd month of follow-up after wound healing(T0 stage).Basic information and scar VSS and PSAS scores were recorded for Group A and Group B.Scar thickness was measured using high-frequency ultrasound,and topical anti-scar medication and compression therapy were administered as prescribed from month 3 to month 6,while Group A volunteers received ion beam therapy three times at one-month intervals in months 3,4 and 5 after discharge.The scar was scored,measured and recorded again for both groups at the 6th month follow-up(T1 period).Finally,22 volunteers in Group A completed treatment and follow-up,including 12 males and 10 females,aged20.682±15.536 years,with scars located on the face and neck in 5 cases,the extremities in12 cases and the trunk in 5 cases,and the causes of burns were flames(12 cases)and hot liquids(10 cases)respectively;21 volunteers in Group B completed treatment and follow-up,including 11 males and 10 females,aged 26.429±12.552 years old,with one scar on the face and neck,16 on the extremities and four on the trunk,and the causes of burns were flame(12cases)and hydrothermal fluid(9 cases).Results A total of 22 patients in group A and 21 patients in group B completed the study,with total VSS and PSAS scores of 12.136±1.167,8.000±1.662 and 37.909±5.605,18.909±3.598 at T0 and T1,respectively,and statistically significant improvements in the colour,vascular distribution,thickness,regularity and pain and itching of the scar under the subjective assessment of the physicians and patients in group A(P<0.001).The total VSS and PSAS scores of patients in group B were 11.524±1.946 at T0 and T1,respectively.There was a statistically significant improvement in the colour,vascular distribution,thickness,softness,regularity and pain and itching of the keloid scars as assessed by the physicians and patients.There was a slight increase in thickness.The greatest post-treatment improvement in the total scar VSS score(0.388±0.122)was seen in patients in group A when scar thickness(H)was statistically significantly improved at stage T1(3.448±1.560)compared to stage T0(4.950±2.245)and when H was ≤4mm as measured by HF ultrasound;patients in group B when scar thickness(H)was statistically significantly improved at stage T1(4.505±1.271)compared to stage T0(4.400)There were no serious adverse effects such as localised infection,hyperpigmentation,or aggravation of scarring observed in patients in Group A after micro plasma beam treatment.Conclusion 1.In the proliferative phase of scarring,micro plasma beam combined with compression therapy and silicone drugs is more effective than compression therapy and silicone drugs alone in the treatment of post-burn proliferative keloid scars.2.Micro plasma beam therapy HS can improve the colour,vascular distribution,thickness,softness and regularity of the scar,reduce the sensation of itching and pain in the scar with minimal adverse effects.3.For keloid scars smaller than 4mm,micro plasma beam treatment is more effective. |
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