Application Effect And Safety Analysis Of Sodium Picosulfate In Bowel Preparation

Object:To observe the application effect and safety of Sodium picosulfate in bowel preparation before colonoscopy,and provide evidence for clinical application of Sodium picosulfate in bowel preparation.Methods:A total of 1000 patients who underwent colonoscopy for the first time at the Digestive Endoscopy Center of a third-class hospital from August 2021 to August 2022,were randomly divided into test group and control group with 500 patients in each group,respectively.Sodium picosulfate was used for bowel preparation in test group while Polyethylene glycol electrolyte was used in control group.General data of patients was collected.The endoscopists objectively evaluated the cleanliness of bowel according to the Boston Bowel Preparation Scale.The bowel cleanliness,intestinal cleanliness pass rate,cecal arrival rate,polyp and adenoma detection rate,taking experience(taste)and price acceptance,adverse reaction incidence,and blood biochemical indicators before and after medication were compared between the two groups.The data were analyzed using SPSS20.0 software.Results:1.There was no statistically difference between the test group and the control group in the cleaning effect of the left colon,transverse colon,right colon,and whole colon(P>0.05);There was no significant difference in the qualified rate of the left colon,transverse colon,right colon and total intestinal cleaning between the test group and the control group(P>0.05).For patients with diabetes,constipation,and obesity,the intestinal cleaning effect of the sodium picosulfate was similar to that of the polyethylene glycol electrolyte(P>0.05).2.Logistic regression analysis showed that age,obesity,diabetes,and constipation were closely related to the quality of bowel preparation for colonoscopy,with OR values of 0.917,0.662,0.761,and 0.835,respectively.3.The success rate of cecal arrival was 100% in both the control and trial groups.4.In the detection rate of polyps and adenomas,detection rate of polyps and adenomas in the test group was 47.2% and 33.2%,respectively,while the detection rate of polyps and adenomas in the control group was 46.4% and 36.6%,respectively.There was no statistically significant difference between the two groups(P>0.05).In the test group and the control group,the detection rate of polyps and adenomas in diabetes patients was higher than that in non-diabetes patients,the detection rate of polyps and adenomas in obese patients was higher than that in non-obese patients,and the detection rate of polyps and adenomas in constipation patients was higher than that in non-constipation patients(P<0.05).In the test group and the control group,there was no significant difference in the detection rate of polyps and adenomas between the two intestinal preparation methods for diabetes patients,obese patients,and constipation patients(P>0.05).With the growth of age,the detection rate of polyps and adenomas increased,and the difference between different age groups was statistically significant(P<0.05).At the same withdrawal time(WT),the detection rate of polyps and adenomas in the test group was not significantly different from that in the control group(P>0.05),but with the increase of the withdrawal time,the detection rate of polyps and adenomas increased.The detection rate of polyps and adenomas in the group with a withdrawal time ≥ 9 min was higher than that in the 6-9 min group and ≤ 5min group and the detection rate of polyps and adenomas in the 6-9 min group was higher than that in the ≤ 5 min group(P<0.05).5.The incidence of adverse reactions in the test group was lower than that in the control group.Adverse reactions occurred in 8 cases in the test group and 17 cases in the control group.There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Among various adverse reactions,there was no significant difference in the incidence rates of allergy,inflammation,nausea and vomiting,and abdominal distension and abdominal pain(P>0.05).6.There was no significant difference in the changes in blood potassium,blood sodium,blood chlorine,blood calcium,blood magnesium,blood phosphorus,serum creatinine,and urea nitrogen levels between the test group and the control group before and after treatment(P>0.05).7.The taste acceptance of the patients in the test group was significantly higher than that in the control group(P=0.000),but the price affordability of the patients in the test group was lower than that in the control group(P=0.000).Conclusion:1.There was no difference between the Sodium Picosulfate group and the polyethylene glycol electrolyte group in bowel cleansing effect,colonoscopy completion rate,adenoma and polyp detection rate.2.According to the data in this group,after the intervention of a low residue diet one day before the examination in special populations(diabetes,obesity,constipation),there was no statistical difference between the efficacy of Sodium Picosulfate group in bowel cleaning,the completion rate of total colonoscopy,the detection rate of adenomas and polyps and that of polyethylene glycol electrolyte group.3.The adverse reactions,changes of electrolyte and renal function of the Sodium Picosulfate group were not different from those of the polyethylene glycol electrolyte before and after the examination,and the safety was high,and the taste acceptance of the drug was higher than that of the polyethylene glycol electrolyte group.Sodium Picosulfate can be used as a better choice for bowel preparation.