Observation Of The Efficacy On Bowel Preparation Before Colonoscopy By Different Directions Of Oral Compound Polyethylene Glycol-electrolyte Powder

Objectives:To understand the directions of compound polyethylene glycol-electrolyte powder(SF-PEG)in bowel preparation before colonoscopy and to explore the highest efficacy method in bowel preparation with less adverse reaction,better tolerance and more widely acceptance by dosage and direction comparison.Methods:A total of 671 patients undergoing colonoscopy in the department of Endoscopy in Shandong Provencal Hospital from Sep.1st 2016 to Oct.31st 2016 were randomly allotted into group A,B and C in accordance with the random number table.SF-PEGs were applied as the oral preparations in all groups with different directions.Patients in group A intake 3Lof SF-PEG(4 boxes)on the day of colonoscopy.While the ones in group B took 0.75L of SF-PEG(1 box)at the night before colonoscopy,and the other 2.25L(3 boxes)on the day check.In the meantime,individuals in group C intake 0.2g of phenolphthalein tablets in the night before the check and ingested 2.25L of SF-PEG(3 boxes)on the day check.Boston Bowel Preparation scale(BBPS)was applied to evaluate the efficacy of bowel preparation by grading the right colon,transverse colon and left colon respectively and calculating the total points.Contemporarily,the compliance,tolerance and adverse reactions were recorded in all of the patients by questionnaire.The statistical analyses were conducted using the SPSS 22.0 software after data collection and reduction in Excel 2007.Intergroup differences with P<0.05 were regarded as statistically significant,except for multiple comparisons,where adjusted P values of less than 0.0167 were considered statistically significant.The quantitative data are presented as the means(SD).Qualitative data are shown as percentages.Comparisons between three groups were tested with the Kruskal-Wallis test.Meanwhile the chi-square test was used to compare categorical variables.Results:Patients who undergo supplemented clysis after oral preparation,or was diagnosed as colon constriction that affect the bowel preparation,or unfinished the questionnaires were excluded.In all,671 patients were included and were randomly divided into group A(n=219),group B(n=217)and group C(n=235).The average ages of patients were 55.8±10.9,56.5±11.9 and 55.3±11.9 in group A,B and C respectively.And their numbers of male were 97,110 and 104.Statistical analysis showed that there were no significant differences in age and sex among the 3groups(P>0.05).Meanwhile no significant differences were found among 3 groups in history of colonoscopy,constipation,diet control before the check and autonomic activities after SF-PEG intake,as well as BBPS(P>0.05).The incidence rate of adverse reactions in group A was markedly higher than that in group B and C.Therefore,the patients in group B and C had better compliance and tolerance with less rate of adverse reactions when compared with group A(P<0.05).Conclusions:1.More than 89 percent of the patients had fine BBPS score in each group.Therefore,all of the three methods were appropriate for bowel preparation.2.The other factors that might affect the quality of bowel preparation,such as,the history of colonoscopy and constipation,diet control before the check and autonomic activities after SF-PEG intake,were comparable among the 3 groups.3.The method in group B and C possessed well cleaning efficacy and safety with less adverse reactions.Contemporarily,the one in group C cost less because of the use of phenolphthalein,which reduced the dosage of SF-PEG to 2.25L,so it would be fit for widely applied.