| Objective: By comparing the clinical efficacy of xiaoliuzhitong paste external application combined with peritoneal perfusion and Simple intraperitoneal perfusion in treating cancerous ascites,observe and evaluate the clinical effect and safety of xiaoliuzhitong paste external application combined with peritoneal perfusion,the aim is to provide an effective Traditional Chinese medicine external application treatment plan for patients with cancerous ascites.Methods: Selected 50 patients who met the inclusion criteria,All the patients were from October 2021 to October 2022,and they were admitted to the Shijiazhuang Hospital of Traditional Chinese Medicine.According to the randomized control method,25 patients each in the treatment group and the control group.Both groups were treated with peritoneal cisplatin,and the treatment group added xiaoliuzhitong paste,Treatment for 2 weeks.Recording the maximum diameter of abdominal effusion,flat umbilical abdominal circumference,Traditional Chinese medicine(TCM)symptom score,Caschi functional status score and safety indicators before and after treatment,to evaluate its efficacy.Results:1.Maximum diameter of abdominal cavity effusion:(1)Within-group comparisons: In the treatment group,the maximum diameter of the abdominal effusion was decreased(P < 0.05);The abdominal effusion also decreased in maximum diameter in the control group(P < 0.05).(2)Comparison between the groups after treatment: the two groups difference were not significant(P > 0.05).2.Effective control rate of ascites: The effective control rate of ascites in the treatment group was 81.82%,which was higher than 71.43% in the control group.However,there was no statistical difference in the comparison between the two groups(P < 0.05).3.Flat umbilical and abdominal circumference:(1)Within-group comparisons: Both groups showed significant reductions in abdominal circumference,the treatment group showed a significant reduction in abdominal circumference and significant statistical differences(P < 0.01);and the control group(P < 0.05).(2)Comparison between the groups after treatment: After treatment,the difference was not significant(P > 0.05).4.Karnofsky functional status score:(1)Within-group comparisons:The KPS score in the treatment group was statistically different(P < 0.01);no statistical difference in the control group(P > 0.05).(2)Comparison between the groups after treatment: The treatment group was better than the control group(P < 0.05).5.Total points of TCM symptoms:(1)Within-group comparisons: the symptoms of TCM in the treatment group improved compared with those before treatment,statistically significant(P < 0.05);not significant in the control group(P > 0.05).(2)Comparison between the groups after treatment:The treatment group was significantly better than the control group,with significant statistical differences(P < 0.01).6.Individual score of TCM symptoms: The treatment group had significant clinical effects in fatigue,poor appetite and abdominal pain,with significant statistical differences(P < 0.01).7.Efficient rate of TCM symptoms: After treatment,there were no recovered cases in either group,and the effective rate of TCM symptoms was 86.36%;the control group was 19.05%;For the response rate between the two groups,the treatment group was higher than the control group,and the statistical difference was significant(P < 0.01).8.Safety evaluation: During the treatment,3 people had adverse skin reactions.The skin appeared red and slightly itchy.After cleaning the drug residue on the skin,local rubbing iodophor could relieve it.The two groups have no statistical difference(P > 0.05).Conclusion:(1)Xiaoliuzhitong paste external application combined with chemotherapy compared to Simple intraperitoneal perfusion can better improve the clinical symptoms and the quality of life,effectively reduce the pain of patients.(2)After adding Xiaoliuzhitong Paste,increased clinical efficacy,without increased adverse drug reactions,and a high degree of safety. |
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