Clinical Study On The Treatment Of Cancerous Ascites By Steaming The Navel With Wenyang Lishui Recipe

[Objective]To observe and evaluate the clinical efficacy and safety of wenyanglishui decoction navel steaming in the treatment of cancerous ascites.[Methods]Using a prospective,single-center,randomized controlled study,40 patients who met the criteria for case selection were randomly divided into a control group and an observation group with 20 patients in each group.Both groups were given nutritional support treatment,the control group was treated with diuretics,the observation group on the basis of the control group combined with wenyanglishui decoction navel steaming method.2 weeks is a course of treatment.The deepest diameter of peritoneal effusion,umbilical abdominal circumference,24-hour urine volume,TCM symptom score,quality of life score,skin adverse reaction,blood routine,liver and kidney function were observed and recorded before and after treatment.Finally,statistical analysis was performed to evaluate its efficacy and safety.[Results]In this study,40 cases were included,and 5 cases were removed.In fact,35 cases were observed,including 18 cases in the observation group and 17 cases in the control group.(1)Comparison of the deepest diameter of ascites dark area:①Intra-group comparison:the deepest diameter of peritoneal effusion was significantly reduced in the observation group after treatment,and the difference was statistically significant(P<0.05).In the control group,there was no significant change in the deepest diameter of peritoneal effusion before and after treatment,and the difference was not statistically significant(P>0.05).②Comparison between two groups:After treatment,the observation group was better than the control group in reducing the deepest diameter of peritoneal effusion,and the difference was statistically significant(P<0.05).(2)Comparison of the efficiency of ascites:The effective control rate of the observation group was 88.89%;The effective control rate of the control group was 70.59%.After statistical test,the difference was not statistically significant(P>0.05).(3)Intra-umbilical abdominal circumference changes:①Intra-group comparison:Intra-umbilical abdominal circumference of the observation group was decreased after treatment compared with before treatment,and the difference was statistically significant(P<0.01).Compared with the control group before and after treatment,the difference was not statistically significant(P>0.05).②Comparison between groups:After treatment,there was no significant difference between the two groups(P>0.05).(4)Comparison of 24-hour urine volume:①Intra-group comparison:the 24-hour urine volume of the observation group increased after treatment compared with before treatment,and the difference was statistically significant(P<0.01).Compared with the control group before and after treatment,the difference was not statistically significant(P>0.05).②Comparison between groups:there was no significant difference between the two groups after treatment(P>0.05).(5)Comparison of the single integral effect of TCM symptoms:The observation group was better than the control group in the aspects of abdominal distension,shortness of breath,appetite loss,nausea and vomiting,abdominal distension after eating,and shortness of urine,with statistically significant differences(P<0.05).(6)Comparison of total score of TCM symptoms:①Comparison within group:the total score of TCM symptoms after treatment was significantly improved compared with that before treatment,and the difference was statistically significant(P<0.01);There was no significant difference between the control group before and after treatment(P>0.05).②Comparison between groups:the observation group was better than the control group in improving TCM symptom scores,and the difference was statistically significant(P<0.05).(7)Comparison of total curative effect of TCM symptoms:No clinical cured cases were found in the two groups after treatment.In the observation group,1 case(5.56%)was significantly effective,12 cases(66.67%)were effective,5 cases(27.78%)were ineffective,and the total effective rate was 72.22%.In the control group,0 cases(0.00%)was significantly effective,5 cases(29.41%)were effective,12 cases(70.59%)were ineffective,and the total effective rate was 29.41%.After statistical analysis,the effective rate of TCM symptoms in the observation group was significantly better than that in the control group,andthe difference was statistically significant(P<0.05).(8)Quality of life comparison:① Intra-group comparison:Life quality score of the observation group was significantly improved after treatment compared with before treatment,with statistically significant difference(P<0.01);Compared with the control group before and after treatment,the difference was not statistically significant(P>0.05).②Comparison between groups:The observation group was better than the control group in improving the quality of life of patients,with statistical significance(P<0.05)(9)Comparison of curative effect on quality of life:In the observation group,there were 13 cases of improvement(72.22%),4 cases of stability(22.22%),and 1 case of decrease(5.56%),with a total effective control rate of 94.44%.In the control group,there were 6 cases of improvement(35.29%),5 cases of stability(29.41%),6 cases of decrease(35.29%),and the total effective control rate was 64.71%.The observation group was superior to the control group in improving the quality of life of patients,and the difference was statistically significant(P<0.05)(10)Safety evaluation:During the treatment,15 patients in the observation group had local discomfort such as slight redness and pruritus,which could be alleviated by cleaning the drug residue after the treatment.Skin rash was seen in 3 patients,but it was not obvious,and could be alleviated after local iodine volts cleaning.No obvious rash or skin ulcer was observed in all patients in the observation group.Blood routine and liver and kidney function examination results of the observation group and the control group were compared before and after the group,and the difference was not statistically significant(P>0.05)[Conclusion]The navel steaming method of wenyanglishui recipe for the treatment of cancerous ascites can effectively reduce the amount of patients’ peritoneal effusion,reduce the umbilical abdominal circumference,increase urine volume,improve clinical symptoms,improve the quality of life,and has a good safety,which is worthy of further clinical research and promotion.