Clinical Observation Of Poria Sini Decoction For Yang-deficiency Insomnia Accompanied With Anxiety

Objective: The purpose of this study was to observe the clinical effect of Poria Sini decoction on yang-deficiency insomnia with anxiety symptoms,and to provide relevant clinical research basis for enriching the means and methods of TCM prescription for insomnia.Methods: In this study,60 patients who were screened by inclusion criteria and exclusion criteria in the second Department of Encephalopathy of Qinhuangdao Hospital of Traditional Chinese Medicine from January2022 to November 2022 were selected.According to random number table method,30 cases were divided into treatment group(Poria Sini Tang flavor)and control group(Wuling capsule group).Both groups were given sleep health education and the treatment course was 4 weeks.Pittsburgh sleep quality index 、 Hamilton anxiety Scale and TCM syndrome scale for insomnia were observed and recorded before and after treatment in the two groups.And the clinical efficacy of the two groups after treatment.spss26.0 statistical software was used to calculate and process the data to explore the effect of Poria Sini decoction on yang-deficiency insomnia accompanied by anxiety.Results: Both the treatment group and the control group completed4-week clinical treatment,and 1 case fell off in each group during the treatment,so 29 cases were finally completed in both groups.(1)There was no significant difference in the general data(gender,age,course of disease)between the two groups before treatment(P > 0.05),and the data between the two groups were comparable.(2)The scores of PSQI scale,HAMA scale and TCM syndrome scale before treatment were comparable between the two groups(P > 0.05);After 4 weeks of treatment,the scores of PSQI scale,HAMA scale and TCM syndrome scale were decreased in both groups after treatment,with statistical significance(P < 0.01).After 4 weeks of treatment,the scores of PSQI scale,HAMA scale and TCM syndrome scale after treatment were compared between the two groups,and the differences were statistically significant(P < 0.05).(3)In terms of the overall effective rate,the clinical effective rate of TCM syndromes in the treatment group and the control group was 86.21%and 72.41%,respectively,with statistical significance(P < 0.05).The clinical effective rate of PSQI score was 82.76% and 68.97%,respectively.In HAMA score,the clinical effective rates were 79.31% and 62.07%,respectively,with statistical significance(P < 0.05).(4)Safety indexes,vital signs,routine hematuria and stool,liver and kidney function,electrocardiogram and other tests before and after treatment were not significantly changed.No obvious adverse reactions were observed in the two groups during treatment.Conclusion:Poria Sini Decoction and Wuling capsule could improve patients’ sleep and relieve anxiety.However,the enhancement of Poria Sini decoction was superior to the Wuling capsule group in improving sleep quality and relieving anxiety.Poria Sini Decoction is effective in treating Yang deficiency insomnia accompanied by anxiety,which is worthy of further clinical promotion and research.