Clinical Observation Of Xuanqing Daozhi Decoction In The Treatment Of Constipation-predominant Irritable Bowel Syndrome With Damp Heat Stagnation Syndrome

ObjectiveBy observing the efficacy of Xuanqing Daozhi Decoction in the treatment of constipation-predominant irritable bowel syndrome(damp-heat stagnation syndrome),from TCM syndrome points,symptom severity(IBS-SSS),quality of life(IBS-QOL),recurrence rate and safety In terms of indicators,evaluate its effectiveness and safety,in order to provide reference for Xuanqing Daozhi Decoction in treating constipation predominant irritable bowel syndrome.Methods112 patients in the Department of Spleen and Gastroenterology of Shanxi Provincial Hospital of Traditional Chinese Medicine were collected,who were diagnosed with constipation-predominant irritable bowel syndrome by Western medicine,and whose TCM syndromes met damp-heat stagnation syndrome.They were divided into trial group and control group according to the principle of random grouping,and 56 cases each.The trial group was given traditional Chinese medicine Xuanqing Daozhi Decoction(granules),200 ml each time,twice in the morning and evening,and the control group was given linaclotide capsule,1 time a day,1 capsule each time,30 minutes before breakfast.From the4 th week after stopping the medicine,the patients were followed up by telephone,and the TCM syndrome points,IBS-SSS,IBS-QOL,recurrence rate,and safety were recorded before and after treatment,and the efficacy of TCM was comprehensively evaluated.Result1.Finally included in the statistical analysis,51 cases in the trial group and 50 cases in the control group.The general information is balanced and comparable.2.Comparison of the overall efficacy of TCM syndrome:After treatment,the number of clinically cured,markedly effective,effective,and ineffective cases in the trial group was6,29,11,and 5,and the total effective rate was 90.20%;the clinical recovery,markedly effective,effective,and ineffective cases in the control group The numbers were 2,17,18,13,and the total effective rate was 74.00%.The comprehensive curative effect of the trial group was better than that of the control group(P<0.05).3.TCM total points and single symptom points:After treatment,the total points of both groups decreased,and the trial group was better than the control group(P<0.05);Both groups could relieve dry stool,difficulty in defecation,abdominal distension and abdominal pain,and increase the frequency of defecation(P<0.05);The effect of the trial group was better than that of the control group in terms of improving the main symptoms of difficulty in defecation,abdominal distension,abdominal pain,frequency of defecation,and secondary symptoms of head-heavy limbs,anal burning,and short red urine;In terms of reducing dry stool and sticky mouth,the efficacy is similar(P>0.05).4.Comparison of IBS-SSS points:After treatment,the IBS-SSS points of both groups decreased,and the difference was statistically significant after comparison within the group(P<0.05);the difference was statistically significant after comparison between groups,and the effect of the trial group was better than that of the control group(P<0.05).5.Comparison of IBS-QOL points:After treatment,the two groups were compared within the group,and there was no statistical significance between the experimental group and the control group in terms of behavioral disorder,social function,sexual function,and interpersonal relationship before and after treatment(P>0.05),and the differences in the remaining four dimensions were statistically significant(P < 0.05);the comparison between the two groups showed no statistical significance in terms of behavioral disorder,social function,sexual function,and interpersonal relationship(P > 0.05),and the differences in the remaining four dimensions were statistically significant,and the experimental group The effect was better than that of the control group(P<0.05).6.Comparison of recurrence rate:4 cases of recurrence in the trial group,accounting for 8.70%,and 10 cases of recurrence in the control group,accounting for 27.03%.After comparison of the recurrence rate between the two groups,the difference was statistically significant(P<0.05).7.Safety analysis:There were no adverse reactions in the trial group.In the control group,4 patients had mild diarrhea,2 of which were accompanied by abdominal pain,and3 patients had moderate diarrhea,no abnormalities in liver and kidney function.The drug safety of the trial group was good.ConclusionXuanqing Daozhi decoction has a significant effect in improving the symptoms and quality of life of patients with constipation-type irritable bowel syndrome(damp heat stagnation syndrome),without obvious toxic and side effects,and has broad clinical application prospects.